Metformin (biguanide) is a drug widely used for the treatment of type 2 diabetes. This drug
has been used for 60 years as a highly effective antihyperglycemic agent. The search for the …

Mathematical modelling has established itself as a theoretical tool to understand
fundamental aspects of a variety of medical-biological phenomena. The predictive power of …

Metformin has been shown to inhibit glutaminase (GLS) activity and ammonia accumulation
thereby reducing the risk of hepatic encephalopathy in type 2 diabetic patients. Since tumour …

The present study aimed to explore the therapeutic effect and underlying mechanism of
epidermal growth factor (EGF) on the wound healing of diabetic foot ulcers (DFU). A total of …

The goal of this paper is to propose a new mathematical model for the combined effect of
different treatments and lifestyles on the glucose-insulin dynamics of Type 2 diabetes (T2D) …

Metformin (MET), a commonly prescribed medication for managing type 2 diabetes, has
demonstrated various beneficial effects beyond its primary anti-diabetic efficacy. However …

Most patients with severe Type II diabetes mellitus, characterised by both insulin resistance
and β‐cell failure, eventually require insulin therapy. According to the nonlinear dynamics of …

Aim The aim was to develop and validate limited sampling strategy (LSS) models to predict
the area under the plasma concentration–time curve (AUC) for metformin. Methods …

Diabetes mellitus is one of the deadliest diseases affecting millions of people worldwide.
Due to ethical issues, physiological restrictions and high expenses of human …

Backgroud and study aims: Metformin is believed to be the most widely used hypoglycemic
agent in the world. We aimed to investigate the pharmacokinetic/pharmacodynamics …