How can machine learning and multiscale modeling benefit ocular drug development?
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …
drug delivery space, distinctive barriers, and complicated biomechanical processes …
Protein deposition on contact lenses: the past, the present, and the future
D Luensmann, L Jones - Contact Lens and Anterior Eye, 2012 - Elsevier
Proteins are a key component in body fluids and adhere to most biomaterials within seconds
of their exposure. The tear film consists of more than 400 different proteins, ranging in size …
of their exposure. The tear film consists of more than 400 different proteins, ranging in size …
[HTML][HTML] The TFOS International Workshop on Contact Lens Discomfort: report of the contact lens materials, design, and care subcommittee
L Jones, NA Brennan… - … & visual science, 2013 - iovs.arvojournals.org
Examining the role of the contact lens material, design, and the care system is fundamental
to understanding contact lens discomfort (CLD). However, a systematic review that tries to …
to understanding contact lens discomfort (CLD). However, a systematic review that tries to …
Soft contact lenses capable of sustained delivery of timolol
C Alvarez-Lorenzo, H Hiratani… - Journal of …, 2002 - Elsevier
The aim of this work was to evaluate the influence of the composition and the application of
an imprinting technique on the loading capability of weakly crosslinked hydroxyethyl …
an imprinting technique on the loading capability of weakly crosslinked hydroxyethyl …
BCLA CLEAR-Contact lens wettability, cleaning, disinfection and interactions with tears
Contact lens materials have undergone significant changes over the past 20 years,
particularly with respect to the introduction of silicone hydrogel materials. Whilst this …
particularly with respect to the introduction of silicone hydrogel materials. Whilst this …
Targeting contact lens induced dryness and discomfort: what properties will make lenses more comfortable
D Fonn - Optometry and Vision Science, 2007 - journals.lww.com
There are about 35 million contact lens wearers in North America, and about half of them are
symptomatic of dryness and discomfort, more commonly experienced at the end of the lens …
symptomatic of dryness and discomfort, more commonly experienced at the end of the lens …
The nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol drug delivery systems
H Hiratani, C Alvarez-Lorenzo - Biomaterials, 2004 - Elsevier
The influence of the composition of soft contact lenses on the achievement of a significant
increase in drug loading and control release capability was evaluated. Four types of timolol …
increase in drug loading and control release capability was evaluated. Four types of timolol …
[HTML][HTML] Tear exchange and contact lenses: a review
Tear exchange beneath a contact lens facilitates ongoing fluid replenishment between the
ocular surface and the lens. This exchange is considerably lower during the wear of soft …
ocular surface and the lens. This exchange is considerably lower during the wear of soft …
Mechanical properties of contact lenses: The contribution of measurement techniques and clinical feedback to 50 years of materials development
TS Bhamra, BJ Tighe - Contact Lens and Anterior Eye, 2017 - Elsevier
Purpose This review summarises the way in which mechanical property measurements
combined with clinical perception have influenced the last half century of materials evolution …
combined with clinical perception have influenced the last half century of materials evolution …
[HTML][HTML] The TFOS International Workshop on Contact Lens Discomfort: report of the contact lens interactions with the ocular surface and adnexa subcommittee
The report of this subcommittee concerns the impact of contact lenses (CLs) on the ocular
surface, with a particular emphasis on CL discomfort (CLD). We define the ocular surface, its …
surface, with a particular emphasis on CL discomfort (CLD). We define the ocular surface, its …