Recent advances in the development of pyrazole derivatives as anticancer agents

Y Zhang, C Wu, N Zhang, R Fan, Y Ye, J Xu - International Journal of …, 2023 - mdpi.com
Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical
structures that confer them with a broad spectrum of pharmacological activities. They have …

Copper pyrazole complexes as potential anticancer agents: evaluation of cytotoxic response against cancer cells and their mechanistic action at the molecular level

M Ghorbanpour, A Shayanfar, B Soltani - Coordination Chemistry Reviews, 2024 - Elsevier
This review-based study presents the anticancer potential of pyrazole-based copper
complexes, aiming to evaluate their mechanistic action at the molecular level and find …

Dinuclear doubly bridged phenoxido copper (II) complexes as efficient anticancer agents

SS Massoud, FR Louka, NMH Salem… - European Journal of …, 2023 - Elsevier
Abstract Two cationic [Cu 2 (L 1-2) 2](ClO 4) 2 (1, 2), and four neutral doubly bridged-
phenoxido-copper (II) complexes [Cu 2 (L 3-4) 2](3, 4) and [Cu 2 (L 5-6) 2 (H 2 O)]‧ 2H 2 O …

Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations

L Gao, A Zhang - Frontiers in Immunology, 2023 - frontiersin.org
Copper, a transition metal, serves as an essential co-factor in numerous enzymatic active
sites and constitutes a vital trace element in the human body, participating in crucial life …

Metal complexes derived from bidentate ligands: Synthesis, catalytic and biological applications

DI Ugwu, J Conradie - Inorganica Chimica Acta, 2023 - Elsevier
This review focusses on metal complexes containing bidentate ligands. The development in
the synthesis and some applications of these complexes, reported mainly in the last two …

Coordination behavior of cocaine toward d-block metal ions: synthesis, spectral analysis, density functional theory (DFT) studies, and chemotherapeutic activity

AM Abdallah, NG Zaki, AM El Kerdawy… - Journal of Molecular …, 2023 - Elsevier
The exploration of novel bioactive metallopharmaceuticals for the treatment of diseases
such as microbial infections or cancer, with a focus on reducing side effects and drug …

An updated overview on nitrogen-rich azole-based gold coordination complexes as potent anticancer agents

M Ghorbanpour, B Soltani - Coordination Chemistry Reviews, 2025 - Elsevier
The ability of gold-based complexes in diagnosis and treatment of cancers as the main
worldwide health problems, along with the successful clinical reports of bioactive azole …

Copper (ii) complexes of the CuN 4 S core: selective cytotoxicity to cancerous cells, ROS generation and induction of apoptosis

K Malakar, B Selvakumaran, M Murali… - New Journal of …, 2023 - pubs.rsc.org
Eight novel mixed-ligand copper (II) complexes of the type [Cu (L)(phen)](ClO4)(1–8)
synthesized from S-methyldithiocarbazate Schiff bases [H (L1)–H (L8)] and 1, 10 …

Synthesis, Crystal Structure and Antibacterial Activity of Cu (II) Complex with Nitrogen Donor Pyrazolyl Borate Derivatives

B Soltani, M Ghorbanpour, S Bagheri… - Pharmaceutical …, 2023 - publish.journalgazett.co.in
Background: Pyrazolyl borate derivatives are versatile ligands that can be coordinated with
transition metals and formated a variety of different coordination modes. Copper complexes …

Coordination Behavior of Cocaine Toward d-Block Metal Ions: Synthesis, Spectral Analysis, DFT Studies, And Chemotherapeutic Activity

AM Abdallah, NG Zaki, AM El Kerdawy, WH Mahmoud… - papers.ssrn.com
The study of new bioactive metallopharmaceuticals for the treatment of diseases like
microbial infections or cancer with a reduction in side effects and drug resistance is an active …