Breast cancer: Biology, biomarkers, and treatments

K Barzaman, J Karami, Z Zarei, A Hosseinzadeh… - International …, 2020 - Elsevier
During the past recent years, various therapies emerged in the era of breast cancer. Breast
cancer is a heterogeneous disease in which genetic and environmental factors are involved …

Plant and animal small RNA communications between cells and organisms

X Chen, O Rechavi - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Since the discovery of eukaryotic small RNAs as the main effectors of RNA interference in
the late 1990s, diverse types of endogenous small RNAs have been characterized, most …

Effect of exosomal miRNA on cancer biology and clinical applications

Z Sun, K Shi, S Yang, J Liu, Q Zhou, G Wang, J Song… - Molecular cancer, 2018 - Springer
Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely
present in various body fluids. Recently, microRNAs (miRNAs) have been identified in …

Circulating microRNAs in cancer: potential and challenge

M Cui, H Wang, X Yao, D Zhang, Y Xie, R Cui… - Frontiers in …, 2019 - frontiersin.org
MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be
secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs …

Mechanisms of mesenchymal stem/stromal cell function

JL Spees, RH Lee, CA Gregory - Stem cell research & therapy, 2016 - Springer
The past decade has seen an explosion of research directed toward better understanding of
the mechanisms of mesenchymal stem/stromal cell (MSC) function during rescue and repair …

Extracellular vesicles and particles impact the systemic landscape of cancer

S Lucotti, CM Kenific, H Zhang, D Lyden - The EMBO journal, 2022 - embopress.org
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …

MSC exosome works through a protein-based mechanism of action

WS Toh, RC Lai, B Zhang, SK Lim - Biochemical Society …, 2018 - portlandpress.com
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …

Exosomes in cancer: small particle, big player

X Zhang, X Yuan, H Shi, L Wu, H Qian, W Xu - Journal of hematology & …, 2015 - Springer
Exosomes have emerged as a novel mode of intercellular communication. Exosomes can
shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs …

Cancer-associated fibroblasts—heroes or villains?

KA Gieniec, LM Butler, DL Worthley… - British journal of cancer, 2019 - nature.com
Cancer-associated fibroblasts (CAFs) were originally presumed to represent a
homogeneous population uniformly driving tumorigenesis, united by their morphology and …

Exosomes as miRNA carriers: formation–function–future

X Yu, M Odenthal, JWU Fries - International journal of molecular sciences, 2016 - mdpi.com
Exosomes, which are one of the smallest extracellular vesicles released from cells, have
been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs …