[HTML][HTML] Cell fate decisions, transcription factors and signaling during early retinal development

R Diacou, P Nandigrami, A Fiser, W Liu… - Progress in retinal and …, 2022 - Elsevier
The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Specialized subpopulations of deep-layer pyramidal neurons in the neocortex: bridging cellular properties to functional consequences

A Baker, B Kalmbach, M Morishima, J Kim… - Journal of …, 2018 - Soc Neuroscience
Neocortical pyramidal neurons with somata in layers 5 and 6 are among the most visually
striking and enigmatic neurons in the brain. These deep-layer pyramidal neurons (DLPNs) …

A multimodal cell census and atlas of the mammalian primary motor cortex

Principal manuscript editors, Analysis coordination… - Nature, 2021 - nature.com
Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

Genetic dissection of the glutamatergic neuron system in cerebral cortex

KS Matho, D Huilgol, W Galbavy, M He, G Kim, X An… - Nature, 2021 - nature.com
Diverse types of glutamatergic pyramidal neurons mediate the myriad processing streams
and output channels of the cerebral cortex,, yet all derive from neural progenitors of the …

Chromosome 10q26–driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium

BL Williams, NA Seager, JD Gardiner… - Proceedings of the …, 2021 - National Acad Sciences
Genome-wide association studies have identified the chromosome 10q26 (Chr10) locus,
which contains the age-related maculopathy susceptibility 2 (ARMS2) and high temperature …

Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

M Lattke, R Goldstone, JK Ellis, S Boeing… - Nature …, 2021 - nature.com
Astrocytes have essential functions in brain homeostasis that are established late in
differentiation, but the mechanisms underlying the functional maturation of astrocytes are not …

[HTML][HTML] Regulatory roles for SOX11 in development, stem cells and cancer

SM Tsang, E Oliemuller, BA Howard - Seminars in cancer biology, 2020 - Elsevier
The transcription factor SOX11 (SRY-related high-mobility-group (HMG) box 11), a member
of the SOXC group, is expressed during embryogenesis but largely absent in most adult …

Chromatin remodeling complex NuRD in neurodevelopment and neurodevelopmental disorders

A Hoffmann, D Spengler - Frontiers in genetics, 2019 - frontiersin.org
The nucleosome remodeling and deacetylase (NuRD) complex presents one of the major
chromatin remodeling complexes in mammalian cells. Here, we discuss current evidence for …

A comprehensive temporal patterning gene network in Drosophila medulla neuroblasts revealed by single-cell RNA sequencing

H Zhu, SD Zhao, A Ray, Y Zhang, X Li - Nature communications, 2022 - nature.com
During development, neural progenitors are temporally patterned to sequentially generate a
variety of neural types. In Drosophila neural progenitors called neuroblasts, temporal …

RbAp48 protein is a critical component of GPR158/OCN signaling and ameliorates age-related memory loss

S Kosmidis, A Polyzos, L Harvey, M Youssef… - Cell reports, 2018 - cell.com
Precisely deciphering the molecular mechanisms of age-related memory loss is crucial to
create appropriate therapeutic interventions. We have previously shown that the histone …