Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

Teleost fish are unique among vertebrates in that phenotypic sex or onset of sex inversion
can be easily manipulated by hormonal treatments. In recent years, researchers have begun …

When looking for a book on fish toxicology, you might find one that discusses the
biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You …

In mammals, myocardial cell death due to infarction results in scar formation and little
regenerative response. In contrast, zebrafish have a high capacity to regenerate the heart …

Kidney function depends on the nephron, which comprises a blood filter, a tubule that is
subdivided into functionally distinct segments, and a collecting duct. How these regions …

The Wilms tumor protein WT1 is an essential factor for kidney development. In humans,
mutations in WT1 lead to Wilms tumor, a pediatric kidney cancer as well as to developmental …

The present work reviews the latest information on the cellular, molecular and physiological
aspects of sexual determination and differentiation in teleost fish. The group exhibits a large …

Renal hypodysplasia (RHD) is characterized by reduced kidney size and/or
maldevelopment of the renal tissue following abnormal organogenesis. Mutations in renal …

Vertebrates form a progressive series of up to three kidney organs during development—the
pronephros, mesonephros, and metanephros. Each kidney derives from the intermediate …

The zebrafish is a valuable vertebrate model for kidney research. The majority of previous
studies focused on the zebrafish pronephros, which comprises only two nephrons and is …