DNA quadruple helices in nanotechnology

JL Mergny, D Sen - Chemical Reviews, 2019 - ACS Publications
DNA has played an early and powerful role in the development of bottom-up
nanotechnologies, not least because of DNA's precise, predictable, and controllable …

Guidelines for G-quadruplexes: I. In vitro characterization

Y Luo, A Granzhan, J Marquevielle, A Cucchiarini… - Biochimie, 2023 - Elsevier
Besides the well-known DNA double-helix, non-canonical nucleic acid structures regulate
crucial biological activities. Among these oddities, guanine-rich DNA sequences can form …

Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array

J Chen, BL Hickey, L Wang, J Lee, AD Gill, A Favero… - Nature Chemistry, 2021 - nature.com
The secondary structures of nucleic acids have an important influence on their cellular
functions but can be difficult to identify and classify quickly. Here, we show that an arrayed …

G-quadruplex forming sequences in the genes coding for cytochrome P450 enzymes and their potential roles in drug metabolism

M Saad, R Zhang, A Cucchiarini, C Mehawej… - Biochimie, 2023 - Elsevier
The majority of drugs are metabolized by cytochrome P450 (CYP) enzymes, primarily
belonging to the CYP1, CYP2 and CYP3 families. Genetic variations are the main cause of …

ASC-G4, an algorithm to calculate advanced structural characteristics of G-quadruplexes

M Farag, C Messaoudi, L Mouawad - Nucleic Acids Research, 2023 - academic.oup.com
ASC-G4 is an algorithm for the calculation of the advanced structural characteristics of G-
quadruplexes (G4). It allows the unambiguous determination of the intramolecular G4 …

Topology of DNA G-Quadruplexes Can Be Harnessed in Holliday Junction-Based DNA Suprastructures to Control and Optimize Their Biocatalytic Properties

D Qiu, M Cheng, P Stadlbauer, J Chen, M Langer… - ACS …, 2023 - ACS Publications
The nature, composition, and topology of the active sites of both natural and artificial
enzymes are key determinants of their catalytic performance. While interesting structural …

High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A π-stacking interactions for small-molecule recognition

A Ou, JW Schmidberger, KA Wilson… - Nucleic acids …, 2020 - academic.oup.com
Aberrant KRAS signaling is a driver of many cancers and yet remains an elusive target for
drug therapy. The nuclease hypersensitive element of the KRAS promoter has been …

Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites

E Gazanion, L Lacroix, P Alberti, P Gurung… - PLoS …, 2020 - journals.plos.org
Mechanisms of transcriptional control in malaria parasites are still not fully understood. The
positioning patterns of G-quadruplex (G4) DNA motifs in the parasite's AT-rich genome …

Stable and conserved G-quadruplexes in the long terminal repeat promoter of retroviruses

E Ruggiero, M Tassinari, R Perrone… - ACS infectious …, 2019 - ACS Publications
Retroviruses infect almost all vertebrates, from humans to domestic and farm animals, from
primates to wild animals, where they cause severe diseases, including immunodeficiencies …

[HTML][HTML] Identification of putative G-quadruplex DNA structures in S. pombe genome by quantitative PCR stop assay

J Jamroskovic, I Obi, A Movahedi, K Chand, E Chorell… - DNA repair, 2019 - Elsevier
In order to understand in which biological processes the four-stranded G-quadruplex (G4)
DNA structures play a role, it is important to determine which predicted regions can actually …