Guidelines for G-quadruplexes: I. In vitro characterization
Besides the well-known DNA double-helix, non-canonical nucleic acid structures regulate
crucial biological activities. Among these oddities, guanine-rich DNA sequences can form …
crucial biological activities. Among these oddities, guanine-rich DNA sequences can form …
Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array
The secondary structures of nucleic acids have an important influence on their cellular
functions but can be difficult to identify and classify quickly. Here, we show that an arrayed …
functions but can be difficult to identify and classify quickly. Here, we show that an arrayed …
G-quadruplex forming sequences in the genes coding for cytochrome P450 enzymes and their potential roles in drug metabolism
The majority of drugs are metabolized by cytochrome P450 (CYP) enzymes, primarily
belonging to the CYP1, CYP2 and CYP3 families. Genetic variations are the main cause of …
belonging to the CYP1, CYP2 and CYP3 families. Genetic variations are the main cause of …
ASC-G4, an algorithm to calculate advanced structural characteristics of G-quadruplexes
M Farag, C Messaoudi, L Mouawad - Nucleic Acids Research, 2023 - academic.oup.com
ASC-G4 is an algorithm for the calculation of the advanced structural characteristics of G-
quadruplexes (G4). It allows the unambiguous determination of the intramolecular G4 …
quadruplexes (G4). It allows the unambiguous determination of the intramolecular G4 …
Topology of DNA G-Quadruplexes Can Be Harnessed in Holliday Junction-Based DNA Suprastructures to Control and Optimize Their Biocatalytic Properties
The nature, composition, and topology of the active sites of both natural and artificial
enzymes are key determinants of their catalytic performance. While interesting structural …
enzymes are key determinants of their catalytic performance. While interesting structural …
High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A π-stacking interactions for small-molecule recognition
Aberrant KRAS signaling is a driver of many cancers and yet remains an elusive target for
drug therapy. The nuclease hypersensitive element of the KRAS promoter has been …
drug therapy. The nuclease hypersensitive element of the KRAS promoter has been …
Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites
Mechanisms of transcriptional control in malaria parasites are still not fully understood. The
positioning patterns of G-quadruplex (G4) DNA motifs in the parasite's AT-rich genome …
positioning patterns of G-quadruplex (G4) DNA motifs in the parasite's AT-rich genome …
Stable and conserved G-quadruplexes in the long terminal repeat promoter of retroviruses
E Ruggiero, M Tassinari, R Perrone… - ACS infectious …, 2019 - ACS Publications
Retroviruses infect almost all vertebrates, from humans to domestic and farm animals, from
primates to wild animals, where they cause severe diseases, including immunodeficiencies …
primates to wild animals, where they cause severe diseases, including immunodeficiencies …
[HTML][HTML] Identification of putative G-quadruplex DNA structures in S. pombe genome by quantitative PCR stop assay
In order to understand in which biological processes the four-stranded G-quadruplex (G4)
DNA structures play a role, it is important to determine which predicted regions can actually …
DNA structures play a role, it is important to determine which predicted regions can actually …