The genetic basis of major depressive disorder
J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
Gender differences in depression: biological, affective, cognitive, and sociocultural factors
JS Hyde, AH Mezulis - Harvard review of psychiatry, 2020 - journals.lww.com
The odds ratio (OR) for gender differences in major depression is 1.95, averaged meta-
analytically over all ages and nations. The gender difference appears by age 12, OR= 2.37 …
analytically over all ages and nations. The gender difference appears by age 12, OR= 2.37 …
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference
X Meng, G Navoly, O Giannakopoulou, DF Levey… - Nature …, 2024 - nature.com
Most genome-wide association studies (GWAS) of major depression (MD) have been
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD …
Minimal phenotyping yields genome-wide association signals of low specificity for major depression
Minimal phenotyping refers to the reliance on the use of a small number of self-reported
items for disease case identification, increasingly used in genome-wide association studies …
items for disease case identification, increasingly used in genome-wide association studies …
The genetic basis of major depression
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
Predicting polygenic risk of psychiatric disorders
Genetics provides two major opportunities for understanding human disease—as a
transformative line of etiological inquiry and as a biomarker for heritable diseases. In …
transformative line of etiological inquiry and as a biomarker for heritable diseases. In …
Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics
SC Dulawa, DS Janowsky - Molecular psychiatry, 2019 - nature.com
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The
neurobiological mechanisms underlying depression remain poorly understood, although …
neurobiological mechanisms underlying depression remain poorly understood, although …
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Depression is more frequent among individuals exposed to traumatic events. Both trauma
exposure and depression are heritable. However, the relationship between these traits …
exposure and depression are heritable. However, the relationship between these traits …
Major depressive disorder and oxidative stress: a review of peripheral and genetic biomarkers according to clinical characteristics and disease stages
AEK Ait Tayeb, V Poinsignon, K Chappell, J Bouligand… - Antioxidants, 2023 - mdpi.com
Major depressive disorder (MDD) is currently the main cause of disability worldwide, but its
pathophysiology remains largely unknown, especially given its high heterogeneity in terms …
pathophysiology remains largely unknown, especially given its high heterogeneity in terms …