P-glycoprotein: New insights into structure, physiological function, regulation and alterations in disease
The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …
industry. This resistance is a common occurrence in several diseases and is mediated by …
P-glycoprotein: one mechanism, many tasks and the consequences for pharmacotherapy of cancers
A Seelig - Frontiers in oncology, 2020 - frontiersin.org
P-glycoprotein or multidrug resistance protein (MDR1) is an adenosine triphosphate (ATP)
binding cassette transporter (ABCB1) intensely investigated because it is an obstacle to …
binding cassette transporter (ABCB1) intensely investigated because it is an obstacle to …
[HTML][HTML] Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance
The emergence of multidrug treatment resistance presents a hurdle for the successful
chemotherapy of tumours. Ferroptosis, resulting from the iron-dependent accumulation of …
chemotherapy of tumours. Ferroptosis, resulting from the iron-dependent accumulation of …
[HTML][HTML] The ABC gene family in arthropods: comparative genomics and role in insecticide transport and resistance
W Dermauw, T Van Leeuwen - Insect biochemistry and molecular biology, 2014 - Elsevier
About a 100 years ago, the Drosophila white mutant marked the birth of Drosophila genetics.
The white gene turned out to encode the first well studied ABC transporter in arthropods …
The white gene turned out to encode the first well studied ABC transporter in arthropods …
The human ATP-binding cassette (ABC) transporter superfamily
The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …
living organisms and a large number of specific transporters have evolved to carry out this …
ABC transporter research: going strong 40 years on
FL Theodoulou, ID Kerr - Biochemical Society Transactions, 2015 - portlandpress.com
In most organisms, ABC transporters constitute one of the largest families of membrane
proteins. In humans, their functions are diverse and underpin numerous key physiological …
proteins. In humans, their functions are diverse and underpin numerous key physiological …
Lung infections associated with cystic fibrosis
While originally characterized as a collection of related syndromes, cystic fibrosis (CF) is
now recognized as a single disease whose diverse symptoms stem from the wide tissue …
now recognized as a single disease whose diverse symptoms stem from the wide tissue …
Understanding cancer and the anticancer activities of naphthoquinones–a review
KW Wellington - RSC advances, 2015 - pubs.rsc.org
The non-communicable disease, cancer, is one of the major causes of death across the
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …
[HTML][HTML] Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.
M Yoshida, M Kijima, M Akita, T Beppu - Journal of Biological Chemistry, 1990 - Elsevier
(R)-Trichostatin A (TSA) is a Streptomyces product which causes the induction of Friend cell
differentiation and specific inhibition of the cell cycle of normal rat fibroblasts in the G1 and …
differentiation and specific inhibition of the cell cycle of normal rat fibroblasts in the G1 and …
Very important pharmacogene summary
LM Hodges, SM Markova, LW Chinn… - Pharmacogenetics …, 2011 - journals.lww.com
ABCB1 (MDR1) is one of many ubiquitous adenosine triphosphate (ATP)-binding cassette
(ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis [1–3] …
(ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis [1–3] …