Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Chronic obstructive pulmonary disease: epidemiology, biomarkers, and paving the way to lung cancer

K Szalontai, N Gémes, J Furák, T Varga… - Journal of clinical …, 2021 - mdpi.com
Chronic obstructive pulmonary disease (COPD), the frequently fatal pathology of the
respiratory tract, accounts for half a billion cases globally. COPD manifests via chronic …

Spatial-omics: Novel approaches to probe cell heterogeneity and extracellular matrix biology

GC Bingham, F Lee, A Naba, TH Barker - Matrix Biology, 2020 - Elsevier
Complex intercellular interactions as well as biomolecular and biomechanical cues from the
extracellular matrix (ECM) profoundly affect cellular functions. Traditional transcriptomic and …

Single-cell mass cytometric analysis of peripheral immunity and multiplex plasma marker profiling of non-small cell lung cancer patients receiving PD-1 targeting …

P Neuperger, K Szalontai, N Gémes, JÁ Balog… - Frontiers in …, 2023 - frontiersin.org
Introduction The effect of platinum-based chemotherapy (Chem.) and second-or multiple-
line immune checkpoint PD-1 blocking therapy by Nivolumab or Pembrolizumab (ICI) was …

Single-cell immunophenotyping revealed the association of CD4+ central and CD4+ effector memory T cells linking exacerbating chronic obstructive pulmonary …

N Gémes, JÁ Balog, P Neuperger, E Schlegl… - Frontiers in …, 2023 - frontiersin.org
Introduction Tobacco smoking generates airway inflammation in chronic obstructive
pulmonary disease (COPD), and its involvement in the development of lung cancer is still …

Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies

C Bourreau, L Treps, S Faure, D Fradin… - Pharmacology & …, 2023 - Elsevier
While new targeted therapies have considerably changed the treatment and prognosis of
non-small cell lung cancer (NSCLC), they are frequently unsuccessful due to primary or …

Characterization of obesity-related diseases and inflammation using single cell immunophenotyping in two different diet-induced obesity models

Z Ruppert, P Neuperger, B Rákóczi, N Gémes… - International Journal of …, 2024 - nature.com
Background Obesity is a growing problem worldwide and a major risk factor for many
chronic diseases. The accumulation of adipose tissue leads to the release of significant …

Single cell mass cytometry revealed the immunomodulatory effect of cisplatin via downregulation of splenic CD44+, IL-17A+ MDSCs and promotion of circulating IFN-γ …

JÁ Balog, L Hackler Jr, AK Kovács… - International journal of …, 2019 - mdpi.com
The treatment of metastatic breast cancer remained a challenge despite the recent
breakthrough in the immunotherapy regimens. Here, we addressed the multidimensional …

Immunoprofiling of Drosophila Hemocytes by Single-Cell Mass Cytometry

JÁ Balog, V Honti, É Kurucz, B Kari… - Genomics …, 2021 - academic.oup.com
Single-cell mass cytometry (SCMC) combines features of traditional flow cytometry (ie,
fluorescence-activated cell sorting) with mass spectrometry, making it possible to measure …

Flexible and simultaneous multi-scale bioparticle manipulation to actuate cell and drug delivery utilizing AC electrokinetic-powered microswimmer

H Sun, Z Li, Y Wu, T Chen, H Yang, L Sun - Sensors and Actuators B …, 2024 - Elsevier
Bioparticle trapping and transporting are essential processes for developing an integrated
cell and drug delivery system. Herein, we present a unique platform that effectively …