The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Parkinson's disease (PD) is named in honor of James Parkinson, whose classic
monograph,“An Essay on the Shaking Palsy,” written in 1817, has provided an enduring …

Cajal was probably the first neurobiologist to suggest that plasticity of nerve cells almost
completely disappeared during aging. However, we know today that neural plasticity is still …

Iron‐induced oxidant stress has been implicated in the pathogenesis of Parkinson's disease.
An increasing body of evidence now indicates that in Parkinson's disease the environment …

Parkinson′ s disease (PD) is a progressive extrapyramidal motor disorder. Pathologically,
this disease is characterized by the selective dopaminergic (DAergic) neuronal …

Mice were treated with 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP; 30 mg/kg ip
twice, 16 h apart). This resulted in changes in motor performance and toxic insult of nigral …

Recent information suggests that free radicals are closely involved in the pathogenesis
and/or progression of Parkinson's disease (PD). High-dose levodopa therapy has been …

Objective: To evaluate the nonergot dopamine agonist ropinirole as an adjunct to L-dopa in
a randomized, double-blind trial in PD patients with motor fluctuations. Background: L-dopa …

Three hundred and seventy‐six subjects with advanced Parkinson's disease participated in
a prospective, double‐blind placebo‐controlled study of the dopamine agonist pergolide …

In recent clinical trials, chronic treatment of patients with PD with pramipexole or ropinirole
was associated with a slower decline of imaged striatal dopaminergic signal, compared to …