Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis
M Furue - International journal of molecular sciences, 2020 - mdpi.com
Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …
JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …
Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy
P Pavlidis, A Tsakmaki, E Pantazi, K Li… - Nature …, 2022 - nature.com
The function of interleukin-22 (IL-22) in intestinal barrier homeostasis remains controversial.
Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial …
Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial …
Role of Th22 cells in the pathogenesis of autoimmune diseases
Upon antigenic stimulation, naïve CD4+ T cells differentiate into different subsets and
secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+ T …
secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+ T …
IL-10 and IL-22 in mucosal immunity: driving protection and pathology
HX Wei, B Wang, B Li - Frontiers in Immunology, 2020 - frontiersin.org
The barrier surfaces of the gastrointestinal tract are in constant contact with various
microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the …
microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the …
[HTML][HTML] Focus: skin: current developments in the immunology of psoriasis
F Grän, A Kerstan, E Serfling, M Goebeler… - The Yale journal of …, 2020 - ncbi.nlm.nih.gov
Psoriasis is a frequent inflammatory skin disease. Fundamental research on the
pathogenesis of psoriasis has substantially increased our understanding of skin …
pathogenesis of psoriasis has substantially increased our understanding of skin …
Interleukin-22: immunobiology and pathology
JA Dudakov, AM Hanash… - Annual review of …, 2015 - annualreviews.org
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
Targeting the Janus kinase family in autoimmune skin diseases
Autoimmune skin diseases are characterized by significant local and systemic inflammation
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …
IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer
Y He, W Luo, Y Liu, Y Wang, C Ma… - The Journal of …, 2022 - Am Soc Clin Investig
Bone is a common site of metastasis in lung cancer, but the regulatory mechanism remains
incompletely understood. Osteoclasts are known to play crucial roles in osteolytic bone …
incompletely understood. Osteoclasts are known to play crucial roles in osteolytic bone …
Therapeutic opportunities of the IL-22–IL-22R1 system
R Sabat, W Ouyang, K Wolk - Nature reviews Drug discovery, 2014 - nature.com
Abstract Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells,
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …