GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Apelin is an endogenous peptide identified as a ligand of the G protein-coupled receptor
APJ. Apelin belongs to the family of adipokines, which are bioactive mediators released by …

Background: Elabela/toddler (ELA) is a critical cardiac developmental peptide that acts
through the G-protein–coupled apelin receptor, despite lack of sequence similarity to the …

The results presented herein demonstrate that apelin is expressed and secreted by both
human and mouse adipocytes. Apelin mRNA levels in isolated adipocytes are close to other …

Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is
independently associated with cardiovascular disease. The mainstay of treatment for CKD is …

Objectives: This study sought to explore the role of new biomarkers in heart failure (HF).
Background: We investigated the utility of novel serum markers alone or together with …

Background—Apelin, the endogenous ligand for the novel G protein–coupled receptor APJ,
has major cardiovascular effects in preclinical models. The study objectives were to …

The heart is a highly structured organ consisting of different cell types, including myocytes,
endothelial cells, fibroblasts, stem cells, and inflammatory cells. This pluricellularity provides …

Apelin receptors, present on vascular smooth muscle cells, endothelium, and
cardiomyocytes, are activated by the family of apelin peptides to elicit cardiovascular effects …

To form new blood vessels (angiogenesis), endothelial cells (ECs) must be activated and
acquire highly migratory and proliferative phenotypes. However, the molecular mechanisms …