Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are
distributed throughout the brain. Insulin acts on these receptors to modulate peripheral …

Most diabetic patients describe moderate to severe pain symptoms whose pharmacological
treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results …

Depression is a common comorbid in diabetic patients. The pathophysiologic mechanisms
that relate this comorbidity is not completely elucidated yet, although several lines of …

Diabetes mellitus (DM) induces a large number of diseases of the nervous, cardiovascular,
and some other systems of the organism. One of the main causes of the diseases is the …

Oxidative stress, a key player in diabetic retinopathy (DR), is associated with retinal cell
apoptosis. This study investigated the effect of tocotrienol-rich fraction (TRF), a potent …

Diabetes mellitus is a metabolic disease associated with dysregulated glucose and insulin
levels and an increased risk of developing Alzheimer's disease (AD) later in life. It is thought …

Depression has huge social risks of high incidence, disability, and suicide. Its prevalence
and harm in people with hyperglycemia are 2–3 times higher than in normal people …

Background: Diabetes can impair cognitive performance and lead to dementia. Patients with
type 1 diabetes mellitus (T1DM) are reported with different levels of cognitive dysfunctions in …

Diabetes mellitus and depression are the common comorbid disorders affecting humans
worldwide. There is an unmet need to develop therapeutic strategies to treat both diabetes …

Diabetes mellitus (DM) is one of the most researched metabolic diseases worldwide. It leads
to extensive complications such as cardiovascular disease, nephropathy, retinopathy, and …