Neutrophils in cancer: two sides of the same coin
E Uribe-Querol, C Rosales - Journal of immunology research, 2015 - Wiley Online Library
Neutrophils are the most abundant leukocytes in blood and are considered to be the first line
of defense during inflammation and infections. In addition, neutrophils are also found …
of defense during inflammation and infections. In addition, neutrophils are also found …
The metastasis-promoting roles of tumor-associated immune cells
Tumor metastasis is driven not only by the accumulation of intrinsic alterations in malignant
cells, but also by the interactions of cancer cells with various stromal cell components of the …
cells, but also by the interactions of cancer cells with various stromal cell components of the …
[HTML][HTML] Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis
J Cools-Lartigue, J Spicer, B McDonald… - The Journal of …, 2013 - Am Soc Clin Investig
The majority of patients with cancer undergo at least one surgical procedure as part of their
treatment. Severe postsurgical infection is associated with adverse oncologic outcomes; …
treatment. Severe postsurgical infection is associated with adverse oncologic outcomes; …
Platelets guide the formation of early metastatic niches
M Labelle, S Begum, RO Hynes - Proceedings of the …, 2014 - National Acad Sciences
During metastasis, host cells are recruited to disseminated tumor cells to form specialized
microenvironments (“niches”) that promote metastatic progression, but the mechanisms …
microenvironments (“niches”) that promote metastatic progression, but the mechanisms …
The multifaceted roles neutrophils play in the tumor microenvironment
Neutrophils are myeloid cells that constitute 50–70% of all white blood cells in the human
circulation. Traditionally, neutrophils are viewed as the first line of defense against infections …
circulation. Traditionally, neutrophils are viewed as the first line of defense against infections …
Neutrophils promote liver metastasis via Mac-1–mediated interactions with circulating tumor cells
JD Spicer, B McDonald, JJ Cools-Lartigue, SC Chow… - Cancer research, 2012 - AACR
Although circulating neutrophils are associated with distant metastasis and poor outcome in
a number of epithelial malignancies, it remains unclear whether neutrophils play an active …
a number of epithelial malignancies, it remains unclear whether neutrophils play an active …
Neutrophils: important contributors to tumor progression and metastasis
A Swierczak, KA Mouchemore, JA Hamilton… - Cancer and Metastasis …, 2015 - Springer
The presence of neutrophils in tumors has traditionally been considered to be indicative of a
failed immune response against cancers. However, there is now evidence showing that …
failed immune response against cancers. However, there is now evidence showing that …
On the dual roles and polarized phenotypes of neutrophils in tumor development and progression
H Piccard, RJ Muschel, G Opdenakker - Critical reviews in oncology …, 2012 - Elsevier
Inconsistencies plague our understanding of the role of neutrophils in cancer and the
literature provides evidence for a duality in neutrophil activity on the outcome of cancer …
literature provides evidence for a duality in neutrophil activity on the outcome of cancer …
Neutrophil: a new player in metastatic cancers
M Wu, M Ma, Z Tan, H Zheng, X Liu - Frontiers in immunology, 2020 - frontiersin.org
The interaction between cancer cells and immune cells is important for the cancer
development. However, much attention has been given to T cells and macrophages. Being …
development. However, much attention has been given to T cells and macrophages. Being …
Neutrophils in cancer
LW Treffers, IH Hiemstra, TW Kuijpers… - Immunological …, 2016 - Wiley Online Library
Neutrophils play an important role in cancer. This does not only relate to the well‐
established prognostic value of the presence of neutrophils, either in the blood or in tumor …
established prognostic value of the presence of neutrophils, either in the blood or in tumor …