Emerging tumor-on-chips with electrochemical biosensors

L Lei, B Ma, C Xu, H Liu - TrAC Trends in Analytical Chemistry, 2022 - Elsevier
Cancer, one of the most dangerous diseases with a high mortality rate, has attracted much
attention and interest. Advances in tissue engineering and microfluidics have led to the …

3D cancer models: One step closer to in vitro human studies

N Manduca, E Maccafeo, R De Maria, A Sistigu… - Frontiers in …, 2023 - frontiersin.org
Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed
prolonged progression-free survival over conventional therapies, yet, to date, in only a …

Micro-engineering and nano-engineering approaches to investigate tumour ecosystems

M Kim, M Panagiotakopoulou, C Chen, SB Ruiz… - Nature Reviews …, 2023 - nature.com
The interactions among tumour cells, the tumour microenvironment (TME) and non-tumour
tissues are of interest to many cancer researchers. Micro-engineering approaches and …

Precision biomaterials in cancer theranostics and modelling

D Caballero, CM Abreu, AC Lima, NM Neves, RL Reis… - Biomaterials, 2022 - Elsevier
Despite significant achievements in the understanding and treatment of cancer, it remains a
major burden. Traditional therapeutic approaches based on the 'one-size-fits-all'paradigm …

[HTML][HTML] Immunocompetent cancer-on-chip models to assess immuno-oncology therapy

TI Maulana, E Kromidas, L Wallstabe… - Advanced Drug Delivery …, 2021 - Elsevier
The advances in cancer immunotherapy come with several obstacles, limiting its
widespread use and benefits so far only to a small subset of patients. One of the underlying …

Organ‐on‐a‐chip technologies for biomedical research and drug development: A focus on the vasculature

D Soto Veliz, KL Lin, C Sahlgren - Smart medicine, 2023 - Wiley Online Library
Current biomedical models fail to replicate the complexity of human biology. Consequently,
almost 90% of drug candidates fail during clinical trials after decades of research and …

Go with the flow: modeling unique biological flows in engineered in vitro platforms

EM Wasson, K Dubbin, ML Moya - Lab on a Chip, 2021 - pubs.rsc.org
Interest in recapitulating in vivo phenomena in vitro using organ-on-a-chip technology has
grown rapidly and with it, attention to the types of fluid flow experienced in the body has …

Boosting the clinical translation of organ-on-a-Chip technology

D Caballero, RL Reis, SC Kundu - Bioengineering, 2022 - mdpi.com
Organ-on-a-chip devices have become a viable option for investigating critical physiological
events and responses; this technology has matured substantially, and many systems have …

Bio-inspired microfluidics: A review

K Raj M, J Priyadarshani, P Karan… - …, 2023 - pubs.aip.org
Biomicrofluidics, a subdomain of microfluidics, has been inspired by several ideas from
nature. However, while the basic inspiration for the same may be drawn from the living …

Modeling 3D human tumor lymphatic vessel network using high‐throughput platform

S Lee, H Kang, D Park, J Yu, SK Koh, D Cho… - Advanced …, 2021 - Wiley Online Library
The lymphatic vessel (LV) plays an important role in cancer biology as a major route for
tumor metastasis. Whereas, recent oncoimmunological approaches have focused its role in …