Decades of efforts in engineering in vitro cancer models have advanced drug discovery and
the insight into cancer biology. However, the establishment of preclinical models that enable …

Atherosclerosis is the primary cause of hardening and narrowing arteries, leading to
cardiovascular disease accounting for the high mortality in the United States. For developing …

In the 1900s, researchers established animal models experimentally to induce
atherosclerosis by feeding them with a cholesterol-rich diet. It is now accepted that high …

Bioprinting is a powerful technology with the potential to transform medical device
manufacturing, organ replacement, and the treatment of diseases and physiologic …

Vascular diseases, such as atherosclerosis and thrombosis, are major causes of morbidity
and mortality worldwide. Traditional in vitro models for studying vascular diseases have …

With the growing interest in biochips, numerous efforts have been made to recapitulate a
more reliable and physiologically relevant environment within chips, resulting in significant …

The human circulatory system is a marvelous fluidic system, which is very sensitive to
biophysical and biochemical cues. The current animal and cell culture models do not …

Atherothrombosis, an atherosclerotic plaque disruption condition with superimposed
thrombosis, is the underlying cause of cardiovascular episodes. Herein, a unique design is …

Epithelium and endothelium, occupying a significant proportion of cells in the human body,
play a crucial role in maintaining organs' normal structure and function. Various methods …

Abstract Development of three dimensional (3D) in vitro models to realistically recapitulate
tumor microenvironment has the potential to improve translatability of anti-cancer drugs at …