Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

The gastrointestinal tract is continuously exposed to trillions of commensal microbes,
collectively termed the microbiota, which are environmental stimuli that can direct health and …

Drug platforms that enable the directed delivery of therapeutics to sites of diseases to
maximize efficacy and limit off-target effects are needed. Here, we report the development of …

Interactions between the microbiota and mammalian host are essential for defense against
infection, but the microbial-derived cues that mediate this relationship remain unclear. Here …

An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Depression is a multifaceted psychiatric disorder mainly orchestrated by dysfunction of
neuroendocrine, neurochemical, immune, and metabolic systems. The interconnection of …

The incidence of dementia, a clinical symptom characterized by severe cognitive decline, is
increasing worldwide. Predictive biomarkers are therefore required for early identification …

Recent studies have revealed the connection between amino acid chirality and diseases.
We have previously reported that the gut microbiota produces various d-amino acids in a …

The human microbiome and its metabolic output play an important role in shaping human
health and disease. The host-microbe crosstalk is often characterised using metabolomics …

The gut microbiota may directly or indirectly influence secretion of the orexigenic hormone,
ghrelin, similar to the modulation of satiety inducing GI hormones. Although data …