Reverse transcriptase inhibitors nanosystems designed for drug stability and controlled delivery
An in-depth analysis of nanotechnology applications for the improvement of solubility,
distribution, bioavailability and stability of reverse transcriptase inhibitors is reported. Current …
distribution, bioavailability and stability of reverse transcriptase inhibitors is reported. Current …
Quinquennial review of progress in degradation studies and impurity profiling: an instrumental perspective statistics
Degradation studies of drug give insightful information about the intrinsic stability of the
molecule, the possible degradents formed during shelf life and thus, aid in the subsequent …
molecule, the possible degradents formed during shelf life and thus, aid in the subsequent …
Taming the dynamics in a pharmaceutical by cocrystallization: investigating the impact of the coformer by solid-state NMR
PMJ Szell, JR Lewandowski, H Blade, LP Hughes… - …, 2021 - pubs.rsc.org
Pharmaceuticals in their crystalline state may display a range of dynamics that can affect
their physicochemical properties and chemical stability. With pharmaceutical cocrystals …
their physicochemical properties and chemical stability. With pharmaceutical cocrystals …
[HTML][HTML] Monitoring and optimizing the biocatalytic degradation of efavirenz with immobilized Trametes versicolor laccase on Ti2NTx MXene: A lab-scale wastewater …
ML Malati, A Abrahams, V Chauke, MP Seopela… - Journal of …, 2023 - Elsevier
The study presents efavirenz as a model antiviral drug for enhanced antiviral drug removal
from wastewater using a combined activated sludge and biocatalytic degradation. The …
from wastewater using a combined activated sludge and biocatalytic degradation. The …
Characterization of stress degradation products of nintedanib by UPLC, UHPLC-Q-TOF/MS/MS and NMR: Evidence of a degradation product with a structure alert for …
Nintedanib is an anti-cancer drug used for the treatment of idiopathic pulmonary fibrosis and
non-small cell lung cancer. The purpose of this study was to explore its degradation …
non-small cell lung cancer. The purpose of this study was to explore its degradation …
Forced degradation study of baricitinib and structural characterization of its degradation impurities by high‐resolution mass spectrometry and nuclear magnetic …
S Chaganti, V Dhiman… - Rapid …, 2023 - Wiley Online Library
Rationale Baricitinib (BARI), an inhibitor of Janus kinases 1 and 2 (JAK 1/2), is used for the
treatment of rheumatoid arthritis and COVID‐19. The present study focuses on establishing …
treatment of rheumatoid arthritis and COVID‐19. The present study focuses on establishing …
Critical review on establishment and availability of impurity and degradation product reference standards, challenges faced by the users, recent developments, and …
The reference standards of impurities (IMPs) and degradation products (DPs) are required
by pharmaceutical industry and quality testing laboratories the world over to comply with …
by pharmaceutical industry and quality testing laboratories the world over to comply with …
Stability behaviour of antiretroviral drugs and their combinations. 10: LC-HRMS, LC-MSn, LC-NMR and NMR characterization of fosamprenavir degradation products …
The present study focused upon the forced degradation behaviour of fosamprenavir (FPV),
an antiretroviral drug. A total of six degradation products (DPs) were separated on a non …
an antiretroviral drug. A total of six degradation products (DPs) were separated on a non …
Rapid microwave-assisted hydrolytic degradation of colchicine: In silico ADME/Tox profile, molecular docking, and development of innovative RP-Chromatographic …
NS Abdelwahab, HM Hassan, AMA Magd - Microchemical Journal, 2020 - Elsevier
Colchicine, is a natural amide containing anti-gout treatment with versatile applications.
Microwave assisted hydrolytic degradation is a newly alternative method thought to be more …
Microwave assisted hydrolytic degradation is a newly alternative method thought to be more …
Separation and characterization of degradation impurities of upadacitinib by liquid chromatography and high resolution mass spectrometry
S Chaganti, C Nelapati, D Jain, KR Roshitha… - … of Chromatography B, 2024 - Elsevier
Upadacitinib is an oral Janus Kinase inhibitor used for the treatment of rheumatoid arthritis.
This research focuses on the forced degradation study of upadacitinib and the …
This research focuses on the forced degradation study of upadacitinib and the …