The mismatch repair system is a major pathway that functions in the maintenance of
genomic integrity. It is involved in mitotic and meiotic recombination, apoptosis …

Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of
Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II …

Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …

Early-onset colorectal cancer (EOCRC), defined as that diagnosed before the age of 50,
accounts for 10–12% of all new colorectal cancer (CRC) diagnoses. Epidemiological data …

PURPOSE Hereditary cancer syndromes infer high cancer risks and require intensive
surveillance. Identification of high-risk individuals among patients with colorectal cancer …

Approximately 35% of patients with colorectal cancer (CRC) have a family history of the
disease attributed to genetic factors, common exposures, or both. Some families with a …

Colorectal cancer is one of the most common tumors, and genetic predisposition is one of
the key risk factors in the development of this malignancy. Lynch syndrome and familial …

Simple Summary Carriers of Lynch syndrome (LS) have an increased risk for several types
of tumour, in particular bowel and uterine cancers. LS is caused by inheritance of a faulty …

Multigene panel tests for hereditary cancer syndromes are increasingly utilized in the care of
colorectal cancer (CRC) and polyposis patients. However, widespread availability of panels …

Introduction Up to one third of colorectal cancers show familial clustering and 5% are
hereditary single-gene disorders. Hereditary non-polyposis colorectal cancer comprises …