Stroke most commonly results from occlusion of a major artery in the brain and typically
leads to the death of all cells within the affected tissue. Mitochondria are centrally involved in …

Calcineurin is a eukaryotic Ca2+-and calmodulin-dependent serine/threonine protein
phosphatase. It is a heterodimeric protein consisting of a catalytic subunit calcineurin A …

Mitochondria play a central role in the survival and death of neurons. The detailed
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …

A large body of evidence has appeared over the last 6 years suggesting that nitric oxide
biosynthesis is a key factor in the pathophysiological response of the brain to hypoxia …

Pathogenic mycobacteria survive within macrophages by avoiding lysosomal delivery,
instead residing in mycobacterial phagosomes. Upon infection, the leukocyte-specific …

Tissue infarction, involving death of essentially all cells within a part of the brain, is a
common pathology resulting from stroke and an important determinant of the long-term …

Brain ischemia triggers a complex cascade of molecular events that unfolds over hours to
days. Identified mechanisms of postischemic neuronal injury include altered Ca2+ …

There are three main mechanisms of neuronal cell death which may act separately or
cooperatively to cause neurodegeneration. This lethal triplet of metabolic compromise …

Induction of the mitochondrial permeability transition (MPT) has been implicated in cellular
apoptosis and in ischemia–reperfusion injury. During MPT, a channel in the inner …

Micelles formed from polycaprolactone-b-poly (ethylene oxide)(PCL-b-PEO) diblock
copolymers were investigated as a novel drug delivery system. The affinity of the micelles for …