The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated
tissue clones whose continued propagation is vested in a biologically distinct subset of cells …

The cancer stem cell (CSC) concept has important therapeutic implications, but its
investigation has been hampered both by a lack of consistency in the terms used for these …

On the subject of acute myeloid leukemia (AML), there is little consensus about the target
cell within the hematopoietic stem cell hierarchy that is susceptible to leukemic …

Chronic myeloid leukemia (CML) is probably the most extensively studied human
malignancy. The discovery of the Philadelphia (Ph) chromosome in 19601 as the first …

Background The progression of chronic myelogenous leukemia (CML) to blast crisis is
supported by self-renewing leukemic stem cells. In normal mouse hematopoietic stem cells …

Many cancers seem to depend on a small population of'cancer stem cells' for their continued
growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be …

Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the
Philadelphia chromosome as the sole genetic abnormality into blast crisis, which is often …

The development of stem–cell gene therapy is hindered by the absence of repopulation
assays for primitive human hematopoietic cells. Current methods of gene transfer rely on in …

We have previously reported the development of in vivo functional assays for primitive
human hematopoietic cells based on their ability to repopulate the bone marrow (BM) of …

The discovery of the severe combined immunodeficiency (scid) mouse mutation has
provided a tool for establishment of small animal models as hosts for the in vivo analysis of …