The emerging role of zinc transporters in cellular homeostasis and cancer
E Bafaro, Y Liu, Y Xu, RE Dempski - Signal transduction and targeted …, 2017 - nature.com
Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of
many cellular proteins. Cellular zinc homeostasis involves the opposing action of two …
many cellular proteins. Cellular zinc homeostasis involves the opposing action of two …
NGS technologies as a turning point in rare disease research, diagnosis and treatment
A Fernandez-Marmiesse, S Gouveia… - Current medicinal …, 2018 - ingentaconnect.com
Approximately 25-50 million Americans, 30 million Europeans, and 8% of the Australian
population have a rare disease. Rare diseases are thus a common problem for clinicians …
population have a rare disease. Rare diseases are thus a common problem for clinicians …
Identification of common genetic risk variants for autism spectrum disorder
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
[HTML][HTML] From zinc homeostasis to disease progression: Unveiling the neurodegenerative puzzle
YG Fan, TY Wu, LX Zhao, RJ Jia, H Ren, WJ Hou… - Pharmacological …, 2024 - Elsevier
Zinc is a crucial trace element in the human body, playing a role in various physiological
processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair …
processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair …
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium
R Polimanti, RK Walters, EC Johnson… - Molecular …, 2020 - nature.com
To provide insights into the biology of opioid dependence (OD) and opioid use (ie,
exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173 …
exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173 …
Zinc transporter proteins
AK Baltaci, K Yuce - Neurochemical research, 2018 - Springer
Zinc, which is involved in the structure of all enzyme classes, is a micro nutrient element and
necessary for growth and development. The ability of zinc to function without causing toxic …
necessary for growth and development. The ability of zinc to function without causing toxic …
Lessons in organic fluorescent probe discovery
Fluorescent probes have gained profound use in biotechnology, drug discovery, medical
diagnostics, molecular and cell biology. The development of methods for the translation of …
diagnostics, molecular and cell biology. The development of methods for the translation of …
Impact of zinc transport mechanisms on embryonic and brain development
J Willekens, LW Runnels - Nutrients, 2022 - mdpi.com
The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn
flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence …
flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence …
Growth modulatory role of zinc in prostate cancer and application to cancer therapeutics
PK To, MH Do, JH Cho, C Jung - International journal of molecular …, 2020 - mdpi.com
Zinc is a group IIB heavy metal. It is an important regulator of major cell signaling pathways
in most mammalian cells, functions as an antioxidant and plays a role in maintaining …
in most mammalian cells, functions as an antioxidant and plays a role in maintaining …
A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis
T Ma, L Zhao, J Zhang, R Tang, X Wang, N Liu… - Protein & …, 2022 - academic.oup.com
Zn2+ is required for the activity of many mitochondrial proteins, which regulate mitochondrial
dynamics, apoptosis and mitophagy. However, it is not understood how the proper …
dynamics, apoptosis and mitophagy. However, it is not understood how the proper …