Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

Microtubule-associated protein, Tau has been implicated in Alzheimer's disease for its
detachment from microtubules and formation of insoluble intracellular aggregates within the …

Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based
on 3D migration models has revealed a diversity of invasive migratory schemes reflecting …

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

Integrin adhesions are a structurally and functionally diverse family of transmembrane, multi-
protein complexes that link the intracellular cytoskeleton to the extracellular matrix (ECM) …

Invadopodia are actin-rich protrusions that degrade the extracellular matrix and are required
for penetration through the basement membrane, stromal invasion and intravasation …

Remodeling of extracellular matrix (ECM) is a fundamental cell property that allows cells to
alter their microenvironment and move through tissues. Invadopodia and podosomes are …

Cell migration and invasion is a key driving factor for providing essential cellular functions
under physiological conditions or the malignant progression of tumors following downward …

Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon
binding to target proteins transduces signals encoded by global or subcellular-specific …

The mechanisms by which tumor cells metastasize and the role of endocytic proteins in this
process are not well understood. We report that overexpression of the GTPase RAB5A, a …