Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Type 1 and type 2 diabetes are characterized by chronic inflammation; both diseases
involve pancreatic islet inflammation, while systemic low-grade inflammation is a feature of …

The plasma proteome is the ultimate target for biomarker discovery. It stores an endless
amount of information on the pathophysiological status of a living organism, which is …

Plasma and serum are rich sources of information regarding an individual's health state, and
protein tests inform medical decision making. Despite major investments, few new …

Diabetic neuropathy, with its major clinical sequels, notably neuropathic pain, foot ulcers,
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …

Aims/hypothesis No established blood-based biomarker exists to monitor diabetic
sensorimotor polyneuropathy (DSPN) and evaluate treatment response. The neurofilament …

The role of chronic inflammation in the pathogenesis of type 2 diabetes mellitus and
associated complications is now well established. Therapeutic interventions counteracting …

Diabetic neuropathies are the most frequent complications of diabetes, contributing to high
morbidity, excess mortality, reduced quality of life, and increased healthcare costs …

A novel clustering approach identified five subgroups of diabetes with distinct progression
trajectories of complications. We hypothesized that these subgroups differ in multiple …

OBJECTIVE To investigate the associations between different anthropometric
measurements and development of distal sensorimotor polyneuropathy (DSPN) considering …