Direct targeting of cancer cells with gene therapy has the potential to treat cancer on the
basis of its molecular characteristics. But although laboratory results have been extremely …

The retinoblastoma (RB) family of proteins, including RB1/p105, retinoblastoma‐like 1
(RBL1/p107), and retinoblastoma‐like 2 (RBL2/p130), is principally known for its central role …

Aberrant DNA hypermethylation contributes to myelomagenesis by silencing tumor-
suppressor genes. Recently, a few reports have suggested that a novel class of small non …

Abstract The p16/RB/E2F regulatory pathway, which controls transit through the G1
restriction point of the cell cycle, is one of the most frequent targets of genetic alterations in …

▪ Abstract Lung cancer is the most common cause of cancer death in the United States,
killing more than 156,000 people every year. In the past two decades, significant progress …

The final proof of principle that cancer patients can be effectively treated with angiogenesis
inhibitors is eagerly awaited. Various preclinical in vivo experiments have proven that most …

Diabetes alters microvascular structure and function and is a major risk factor for
cardiovascular diseases. In diabetic skeletal muscle, impaired angiogenesis and reduced …

Between 2000 and 2050, the number of new cancer patients diagnosed annually is
expected to double, with an accompanying increase in treatment costs of more than $80 …

The retinoblastoma tumor suppressor protein Rb plays a major role in regulating G1/S
transition and is a critical regulator of cell proliferation. Rb protein exerts its growth …

OBJECTIVES: To determine the relationship between histopathological prognostic factors
and sites of initial recurrence in endometrioid uterine cancer. METHODS: A total of 355 …