Epigenetic Regulation and Chromatin Remodeling in Malaria Parasites
T Hollin, Z Chahine, KG Le Roch - Annual Review of …, 2023 - annualreviews.org
Plasmodium falciparum, the human malaria parasite, infects two hosts and various cell
types, inducing distinct morphological and physiological changes in the parasite in response …
types, inducing distinct morphological and physiological changes in the parasite in response …
The many paths to artemisinin resistance in Plasmodium falciparum
Emerging resistance against artemisinin (ART) poses a major challenge in controlling
malaria. Parasites with mutations in PfKelch13, the major marker for ART resistance, are …
malaria. Parasites with mutations in PfKelch13, the major marker for ART resistance, are …
Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment
The malaria parasite life cycle includes asexual replication in human blood, with a
proportion of parasites differentiating to gametocytes required for transmission to …
proportion of parasites differentiating to gametocytes required for transmission to …
Malaria parasites do respond to heat
E Tintó-Font, A Cortés - Trends in Parasitology, 2022 - cell.com
The capacity of malaria parasites to respond to changes in their environment at the
transcriptional level has been the subject of debate, but recent evidence has unambiguously …
transcriptional level has been the subject of debate, but recent evidence has unambiguously …
Advances in mass spectrometry-based single cell analysis
Simple Summary Cell-to-cell variation exists within a population of the same cell type due to
stochastic gene and protein expression and environmental factors. Studying such cellular …
stochastic gene and protein expression and environmental factors. Studying such cellular …
Epigenetic and Epitranscriptomic Gene Regulation in Plasmodium falciparum and How We Can Use It against Malaria
R Serrano-Durán, D López-Farfán, E Gómez-Díaz - Genes, 2022 - mdpi.com
Malaria, caused by Plasmodium parasites, is still one of the biggest global health
challenges. P. falciparum is the deadliest species to humans. In this review, we discuss how …
challenges. P. falciparum is the deadliest species to humans. In this review, we discuss how …
Single-cell views of the Plasmodium life cycle
E Real, L Mancio-Silva - Trends in Parasitology, 2022 - cell.com
Malaria-causing Plasmodium parasites undergo multiple phenotypic transitions as they
cycle between diverse niches in the mammalian and mosquito hosts. Recent applications of …
cycle between diverse niches in the mammalian and mosquito hosts. Recent applications of …
Single-cell transcriptomics to define plasmodium falciparum stage transition in the mosquito midgut
M Mohammed, A Dziedziech, V Sekar… - Microbiology …, 2023 - Am Soc Microbiol
Malaria inflicts the highest rate of morbidity and mortality among the vector-borne diseases.
The dramatic bottleneck of parasite numbers that occurs in the gut of the obligatory mosquito …
The dramatic bottleneck of parasite numbers that occurs in the gut of the obligatory mosquito …
Naturally Acquired Kelch13 Mutations in Plasmodium falciparum Strains Modulate In Vitro Ring-Stage Artemisinin-Based Drug Tolerance and Parasite Survival in …
The ring-stage survival assay was utilized to assess the impact of physiological hyperoxic
stress on dihydroartemisinin (DHA) tolerance for a panel of Plasmodium falciparum strains …
stress on dihydroartemisinin (DHA) tolerance for a panel of Plasmodium falciparum strains …
Pervasive sequence-level variation in the transcriptome of Plasmodium falciparum
B Dave, A Kanyal, DV Mamatharani… - NAR Genomics and …, 2022 - academic.oup.com
Single-nucleotide variations (SNVs) in RNA, arising from co-and post-transcriptional
phenomena including transcription errors and RNA-editing, are well studied in a range of …
phenomena including transcription errors and RNA-editing, are well studied in a range of …