The last decade has seen a proliferation of tissue clearing methods that render large
biological samples transparent and allow unprecedented three-dimensional views of …

Summary Three-dimensional (3D) optical imaging techniques can expand our knowledge
about physiological and pathological processes that cannot be fully understood with 2D …

Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are
tightly organized immune cell aggregates that are the central structure of tuberculosis …

The central pathogen-immune interface in tuberculosis is the granuloma, a complex host
immune structure that dictates infection trajectory and physiology. Granuloma macrophages …

The human pathogen Mycobacterium tuberculosis typically causes lung disease but can
also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting …

The pancreatic islets of Langerhans regulate glucose homeostasis. The loss of insulin-
producing β cells within islets results in diabetes, and islet transplantation from cadaveric …

Over the past five years, a rapidly developing experimental approach has enabled high-
resolution and high-content information retrieval from intact multicellular animal (metazoan) …

Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …

Lifelong infection of the gastric mucosa by Helicobacter pylori can lead to peptic ulcers and
gastric cancer. However, how the bacteria maintain chronic colonization in the face of …

Social behaviors are essential for the survival and reproduction of social species. Many, if
not most, neuropsychiatric disorders in humans are either associated with underlying social …