Wnt signaling refers to a conserved signaling pathway, widely studied due to its roles in
cellular communication, cell fate decisions, development and cancer. However, the exact …

The vertebrate central nervous system (CNS) is comprised of vast number of distinct cell
types arranged in a highly organized manner. This high degree of complexity is achieved by …

Global losses of biodiversity are occurring at an unprecedented rate, but causes are often
unidentified. Genomic data provide an opportunity to isolate drivers of change and even …

Wnt signalling plays an eminent role in development, stem cell growth, and tissue
homeostasis. Much of what we know about Wnt signalling, we owe to research in …

Wnts are lipid-modified signaling glycoproteins present in all metazoans that play key roles
in development and homeostasis. Post-translational modifications of Wnts regulate their …

Since the creation of the first transgenic rabbit thirty years ago, pronuclear microinjection
remained the single applied method and resulted in numerous important rabbit models of …

Wnt signalling pathways play pivotal roles in development, homeostasis and human
diseases, and are tightly regulated. We previously identified Tiki as a novel family of Wnt …

The membrane‐tethered protease Tiki antagonizes Wnt3a signaling by cleaving and
inactivating Wnt3a in Wnt‐producing cells. Tiki also functions in Wnt‐receiving cells to …

Abstract Development of the central nervous system in amphibians has called attention from
scientists for over a century. Interested in the matter of embryonic inductions, Hans Spemann …

Renal dysplasia (RD) is a complex congenital disease characterised by abnormal
differentiation of renal tissue (Greco, 2001). Several forms of inherited RD have been …