Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis

A Borrajo, C Spuch, MA Penedo, JM Olivares… - Annals of …, 2021 - Taylor & Francis
The development of effective combined anti-retroviral therapy (cART) led to a significant
reduction in the death rate associated with human immunodeficiency virus type 1 (HIV-1) …

The interplay of HIV-1 and macrophages in viral persistence

CM Hendricks, T Cordeiro, AP Gomes… - Frontiers in …, 2021 - frontiersin.org
HIV-1 has evolved mechanisms to evade host cell immune responses and persist for lifelong
infection. Latent cellular reservoirs are responsible for this persistence of HIV-1 despite the …

The interplay of HIV and autophagy in early infection

R Cabrera-Rodríguez, S Pérez-Yanes… - Frontiers in …, 2021 - frontiersin.org
HIV/AIDS is still a global threat despite the notable efforts made by the scientific and health
communities to understand viral infection, to design new drugs or to improve existing ones …

HIV co-receptor-tropism: cellular and molecular events behind the enigmatic co-receptor switching

S Yandrapally, K Mohareer, G Arekuti… - Critical reviews in …, 2021 - Taylor & Francis
Recognition of cell-surface receptors and co-receptors is a crucial molecular event towards
the establishment of HIV infection. HIV exists as several variants that differentially recognize …

[HTML][HTML] New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs

M Marra, A Catalano, MS Sinicropi, J Ceramella… - Viruses, 2024 - mdpi.com
More than 80 million people worldwide have been infected with the human
immunodeficiency virus (HIV). There are now approximately 39 million individuals living with …

Modulation of Cystatin C in Human Macrophages Improves Anti-Mycobacterial Immune Responses to Mycobacterium tuberculosis Infection and Coinfection With HIV

D Pires, M Calado, T Velez, M Mandal… - Frontiers in …, 2021 - frontiersin.org
Tuberculosis owes its resurgence as a major global health threat mostly to the emergence of
drug resistance and coinfection with HIV. The synergy between HIV and Mycobacterium …

Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages

S Aquaro, A Borrajo, M Pellegrino, V Svicher - Virulence, 2020 - Taylor & Francis
Ongoing with current combinations of antiretroviral drugs for the treatment of Human
Immunodeficiency Virus (HIV) infection can successfully maintain long-term suppression of …

Animal models for studies of HIV-1 brain reservoirs

E Waight, C Zhang, S Mathews… - Journal of Leukocyte …, 2022 - academic.oup.com
The HIV-1 often evades a robust antiretroviral-mediated immune response, leading to
persistent infection within anatomically privileged sites including the CNS. Continuous low …

Learning to be elite: Lessons from HIV-1 controllers and animal models on trained innate immunity and virus suppression

S Sugawara, RK Reeves, S Jost - Frontiers in Immunology, 2022 - frontiersin.org
Although antiretroviral therapy (ART) has drastically changed the lives of people living with
human immunodeficiency virus-1 (HIV-1), long-term treatment has been associated with a …

Microglia: the real foe in HIV-1-associated neurocognitive disorders?

A Borrajo López, MA Penedo, T Rivera-Baltanas… - Biomedicines, 2021 - mdpi.com
The current use of combined antiretroviral therapy (cART) is leading to a significant
decrease in deaths and comorbidities associated with human immunodeficiency virus type 1 …