Background Lung cancer is the most common cause of cancer‐related death in the world,
however lung cancer screening has not been implemented in most countries at a population …

COPD and asthma are important chronic inflammatory disorders with a high associated
morbidity. Much research has concentrated on the role of inflammatory cells, such as the …

Background Exacerbations of chronic obstructive pulmonary disease (COPD) are
associated with accelerated loss of lung function and death. Identification of patients at risk …

Computer-based computed tomography (CT) analysis can provide objective quantitation of
disease in idiopathic pulmonary fibrosis (IPF). A computer algorithm, CALIPER, was …

Rationale: Angiographic investigation suggests that pulmonary vascular remodeling in
smokers is characterized by distal pruning of the blood vessels. Objectives: Using volumetric …

Chronic obstructive pulmonary disease (COPD) is characterized by inflammatory injury to
the intrathoracic airways, lung parenchyma, and pulmonary vasculature in highly variable …

Rationale: Vascular alteration of small pulmonary vessels is one of the characteristic
features of pulmonary hypertension in chronic obstructive pulmonary disease. The in vivo …

Rationale: Chartis Pulmonary Assessment System (Pulmonx Inc., Redwood, CA) is an
invasive procedure used to assess collateral ventilation and select candidates for valve …

Rationale: Impaired exercise ventilatory efficiency (high ventilatory requirements for CO2 [V˙
e/V˙ co2]) provides an indication of pulmonary gas exchange abnormalities in chronic …

Rationale and Objectives The longitudinal relationship between regional air trapping and
emphysema remains unexplored. We have sought to demonstrate the utility of parametric …