TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

Mast cells are hematopoietic cells that reside in virtually all vascularized tissues and that
represent potential sources of a wide variety of biologically active secreted products …

Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …

Mast cells are found resident in tissues throughout the body, particularly in association with
structures such as blood vessels and nerves, and in proximity to surfaces that interface the …

Airway wall remodeling is an established pathological feature in asthma. Its causes are not
well understood, but one mediator of potential relevance is transforming growth factor-beta 1 …

Mast cells and basophils are effector cells in IgE-associated immune responses, such as
those that contribute to asthma and other allergic diseases and to host resistance to …

Mast cells are of hematopoietic origin but typically complete their maturation in peripheral
connective tissues, especially those near epithelial surfaces. Mast cells express receptors …

There have been several recent advances in knowledge about mast cells and basophils in
immune responses, of which some are particularly important: a role has been found for …

Vascular permeability factor/vascular endothelial cell growth factor (VPF/VEGF) can both
potently enhance vascular permeability and induce proliferation of vascular endothelial …

This review describes the role of the mast cell in the pathobiology of skin healing. After
illustrating its main morphofunctional characteristics, with special reference to the dog and …