In the field of neurodegenerative pathologies, the platforms for disease modelling based on
patient-derived induced pluripotent stem cells (iPSCs) represent a valuable molecular …

We have demonstrated that aged animals show significant improvements in cognitive
function and neurogenesis after brain transplantation of human neural stem cells or of …

Adult neurogenesis continuously contributes new neurons to hippocampal circuits and the
programmed death of a subset of immature cells provides a primary mechanism controlling …

In a subset of gliomas, the platelet-derived growth factor (PDGF) signaling pathway is
perturbed. This is usually an early event occurring in low-grade tumors. In high-grade …

Introduction The physiological signals that direct the division and differentiation of the zygote
to form a blastocyst, and subsequent embryonic stem cell division and differentiation during …

Epidemiological and/or experimental studies have shown that unfavorable prenatal
environmental factors, such as stress or exposure to certain neurotoxic environmental …

Although amyloid precursor protein (APP) due to the cytotoxicity of Aβ peptides, has been
intensively studied, the physiological role of APP still remains wrapped up in veil. In this …

This chapter presents a personal account of the work on DNA methylation in viral and
mammalian systems performed in the author's laboratory in the course of the past thirty …

Recent work on embryonic stem (ES) cells showed that stem cell‐derived tissues and
embryos, cloned from ES cell nuclei, often fail to maintain epigenetic states of imprinted …

This chapter presents a personal account of the work on DNA methylation in viral and
mammalian systems performed in the author's laboratory in the course of the past 30 years …