IL-1β and the intestinal epithelial tight junction barrier

LW Kaminsky, R Al-Sadi, TY Ma - Frontiers in immunology, 2021 - frontiersin.org
The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of
contents from the intestinal lumen into the intestinal tissue and systemic circulation. A …

Bench to bedside—new insights into the pathogenesis of necrotizing enterocolitis

DJ Hackam, CP Sodhi - Nature reviews Gastroenterology & hepatology, 2022 - nature.com
Necrotizing enterocolitis (NEC) is the leading cause of death and disability from
gastrointestinal disease in premature infants. Recent discoveries have shed light on a …

Current understanding of IL-37 in human health and disease

Z Su, X Tao - Frontiers in immunology, 2021 - frontiersin.org
IL-37 is a recently discovered cytokine in the IL-1 family exerting broad protective effects on
inflammatory diseases, autoimmune diseases, and cancer. Immune and non-immune cells …

Toll-like receptor 4–mediated enteric glia loss is critical for the development of necrotizing enterocolitis

ML Kovler, AJ Gonzalez Salazar, WB Fulton… - Science translational …, 2021 - science.org
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants, whose
pathogenesis remains incompletely understood, although activation of the Gram-negative …

Necrotizing enterocolitis: Bench to bedside approaches and advancing our understanding of disease pathogenesis

DK Singh, CM Miller, KA Orgel, M Dave… - Frontiers in …, 2023 - frontiersin.org
Necrotizing enterocolitis (NEC) is a devastating, multifactorial disease mainly affecting the
intestine of premature infants. Recent discoveries have significantly enhanced our …

The role of the interleukin-1 family in complications of prematurity

EA Green, SP Garrick, B Peterson, PJ Berger… - International Journal of …, 2023 - mdpi.com
Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of
prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary …

Therapeutic potential of gut microbiota and its metabolite short-chain fatty acids in neonatal necrotizing enterocolitis

NA Alsharairi - Life, 2023 - mdpi.com
Short chain fatty acids (SCFAs), the principle end-products produced by the anaerobic gut
microbial fermentation of complex carbohydrates (CHO) in the colon perform beneficial roles …

Negative regulation of the IL-1 system by IL-1R2 and IL-1R8: Relevance in pathophysiology and disease

D Supino, L Minute, A Mariancini, F Riva… - Frontiers in …, 2022 - frontiersin.org
Interleukin-1 (IL-1) is a primary cytokine of innate immunity and inflammation. IL-1 belongs to
a complex family including ligands with agonist activity, receptor antagonists, and an anti …

The intellectual base and research fronts of IL-37: A bibliometric review of the literature from WoSCC

Y Qin, S Ren, B Shao, H Qin, H Wang, G Li… - Frontiers in …, 2022 - frontiersin.org
Background IL-37 is a recently identified cytokine with potent immunosuppressive functions.
The research fronts of IL-37 are worth investigating, and there is no bibliometric analysis in …

Neurologic consequences of neonatal necrotizing enterocolitis

JA Berken, J Chang - Developmental neuroscience, 2022 - karger.com
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant
with high mortality and morbidity. Children who survive NEC have been shown to …