Optimization of higher-energy collisional dissociation fragmentation energy for intact protein-level tandem mass tag labeling

Y Guo, T Chowdhury, M Seshadri… - Journal of proteome …, 2023 - ACS Publications
Isobaric chemical tag labeling (eg, TMT) is a commonly used approach in quantitative
proteomics, and quantification is enabled through detection of low-mass reporter ions …

Characterizing age-related changes in intact mitochondrial proteoforms in murine hearts using quantitative top-down proteomics

A Ramirez-Sagredo, AT Sunny, KA Cupp-Sutton… - Clinical Proteomics, 2024 - Springer
Abstract Background Cardiovascular diseases (CVDs) are the leading cause of death
worldwide, and the prevalence of CVDs increases markedly with age. Due to the high …

Toward the analysis of functional proteoforms using mass spectrometry-based stability proteomics

J Kang, M Seshadri, KA Cupp-Sutton… - Frontiers in Analytical …, 2023 - frontiersin.org
Functional proteomics aims to elucidate biological functions, mechanisms, and pathways of
proteins and proteoforms at the molecular level to examine complex cellular systems and …

Exploring the Function of Plastoglobules Using Top-down and Bottom-up Proteomics by Capillary Zone Electrophoresis–Mass Spectrometry

Q Wang - 2024 - search.proquest.com
Plastoglobules (PGs) are lipoprotein particles with dynamic morphology and composition
responding to abiotic stress and senescence, and their functions are influenced by …