Interferons (IFNs) are a broad class of cytokines elicited on challenge to the host defense
and are essential for mobilizing immune responses to pathogens. Divided into three classes …

When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their
ability to establish lifelong latent infection in neurons. As for all herpesviruses …

Abstract VirHostNet release 2.0 (http://virhostnet. prabi. fr) is a knowledgebase dedicated to
the network-based exploration of virus–host protein–protein interactions. Since the previous …

Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor
that produced IFN-I and regulated innate immune response, subsequent studies have …

Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …

Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition
to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce …