Enhancers are cis-regulatory elements in the genome that cooperate with promoters to
control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent …

Background The inflammatory response is critical to fight insults, such as pathogen invasion
or tissue damage, but if not resolved often becomes detrimental to the host. A growing body …

Low temperature is a major environmental factor limiting plant growth and crop production.
Epigenetic regulation of gene expression is important for plant adaptation to environmental …

Abstract Purpose of Review Epigenetics is defined as mitotically heritable changes in gene
expression that do not directly alter the DNA sequence. By implication, such epigenetic …

Type 1 diabetes mellitus (T1DM) is caused by an autoimmune destruction of the pancreatic
β-cells, a process in which autoreactive T cells play a pivotal role, and it is characterized by …

Circadian timekeeping is a ubiquitous mechanism that enables organisms to maintain
temporal coordination between internal biological processes and time of the local …

Whole-transcriptome analyses have revealed that a large proportion of the human genome
is transcribed in non-protein-coding transcripts, designated as long non-coding RNAs …

Background Enhancers are non-coding regions of the genome that control the activity of
target genes. Recent efforts to identify active enhancers experimentally and in silico have …

Mechanistic studies in erythroid cells indicate that LDB1, as part of a GATA1/TAL1/LMO2
complex, brings erythroid-expressed genes into proximity with enhancers for transcription …

Delineating the pathophysiology of psychiatric disorders has been extremely challenging
but technological advances in recent decades have facilitated a deeper interrogation of …