Iron acquisition systems of gram-negative bacterial pathogens define TonB-dependent pathways to novel antibiotics

PE Klebba, SMC Newton, DA Six, A Kumar… - Chemical …, 2021 - ACS Publications
Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Bacterial siderophores: diversity, uptake pathways and applications

IJ Schalk - Nature Reviews Microbiology, 2024 - nature.com
Iron is an essential nutrient for the growth, survival and virulence of almost all bacteria. To
access iron, many bacteria produce siderophores, molecules with a high affinity for iron …

[HTML][HTML] Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection

L Spiga, RT Fansler, YR Perera, NG Shealy… - Cell Host & Microbe, 2023 - cell.com
During intestinal inflammation, host nutritional immunity starves microbes of essential
micronutrients, such as iron. Pathogens scavenge iron using siderophores, including …

[HTML][HTML] TonB-dependent transport across the bacterial outer membrane

A Silale, B van den Berg - Annual Review of Microbiology, 2023 - annualreviews.org
TonB-dependent transporters (TBDTs) are present in all gram-negative bacteria and
mediate energy-dependent uptake of molecules that are too scarce or large to be taken up …

Pseudomonas aeruginosa virulence attenuation by inhibiting siderophore functions

GJ Jeong, F Khan, S Khan, N Tabassum… - Applied Microbiology …, 2023 - Springer
Pseudmonas aeruginosa is a Gram-negative bacterium known to be ubiquitous and
recognized as one of the leading causes of infections such as respiratory, urinary tract …

Pseudomonas aeruginosa and its multiple strategies to access iron

IJ Schalk, Q Perraud - Environmental Microbiology, 2023 - Wiley Online Library
Pseudomonas aeruginosa is a ubiquitous bacterium found in many natural and man‐made
environments. It is also a pathogen for plants, animals, and humans. As for almost all living …

[HTML][HTML] Iron acquisition strategies in pseudomonads: mechanisms, ecology, and evolution

R Kümmerli - Biometals, 2023 - Springer
Iron is important for bacterial growth and survival, as it is a common co-factor in essential
enzymes. Although iron is very abundant in the earth crust, its bioavailability is low in most …

Molecules from the microbiome

EE Shine, JM Crawford - Annual review of biochemistry, 2021 - annualreviews.org
The human microbiome encodes a second genome that dwarfs the genetic capacity of the
host. Microbiota-derived small molecules can directly target human cells and their receptors …

The whole is bigger than the sum of its parts: drug transport in the context of two membranes with active efflux

VV Rybenkov, HI Zgurskaya, C Ganguly… - Chemical …, 2021 - ACS Publications
Cell envelope plays a dual role in the life of bacteria by simultaneously protecting it from a
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …

Mechanisms of iron homeostasis in Pseudomonas aeruginosa and emerging therapeutics directed to disrupt this vital process

A Sánchez‐Jiménez, FJ Marcos‐Torres… - Microbial …, 2023 - Wiley Online Library
Pseudomonas aeruginosa is an opportunistic pathogen able to infect any human tissue.
One of the reasons for its high adaptability and colonization of host tissues is its capacity of …