Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

The way in which a cell migrates is influenced by the physical properties of its surroundings,
in particular the properties of the extracellular matrix. How the physical aspects of the cell's …

Cell-substrate interactions play a crucial role in the design of better biomaterials and
integration of implants with the tissues. Adhesion is the binding process of the cells to the …

The architecture of the extracellular matrix (ECM) directs cell behavior by providing spatial
and mechanical cues to which cells respond. In addition to soluble chemical factors …

Human tissues are intricate ensembles of multiple cell types embedded in complex and well-
defined structures of the extracellular matrix (ECM). The organization of ECM is frequently …

Mechanical forces play important roles in the regulation of various biological processes at
the molecular and cellular level, such as gene expression, adhesion, migration, and cell …

Basement membranes possess a complex three-dimensional topography in the nanoscale
and submicron range which have been shown to profoundly modulate a large menu of …

The uniform alignment of endothelial cells inside small-diameter synthetic grafts can be
directed by surface topographies such as microgrooves and microfibers to recapitulate the …

The natural environment of a living cell is not only organized on a micrometer, but also on a
nanometer scale. Mimicking such a nanoscale topography in implantable biomaterials is …

At present, little is known about how endothelial cells respond to spatial variations in fluid
shear stress such as those that occur locally during embryonic development, at heart valve …