A survey on methods for predicting polyadenylation sites from DNA sequences, bulk RNA-seq, and single-cell RNA-seq
Alternative polyadenylation (APA) plays important roles in modulating mRNA stability,
translation, and subcellular localization, and contributes extensively to shaping eukaryotic …
translation, and subcellular localization, and contributes extensively to shaping eukaryotic …
Abnormalities in skeletal muscle myogenesis, growth, and regeneration in myotonic dystrophy
LM André, CRM Ausems, DG Wansink… - Frontiers in …, 2018 - frontiersin.org
Myotonic dystrophy type 1 (DM1) and 2 (DM2) are autosomal dominant degenerative
neuromuscular disorders characterized by progressive skeletal muscle weakness, atrophy …
neuromuscular disorders characterized by progressive skeletal muscle weakness, atrophy …
[HTML][HTML] Elimination of toxic microsatellite repeat expansion RNA by RNA-targeting Cas9
Microsatellite repeat expansions in DNA produce pathogenic RNA species that cause
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2) …
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2) …
APAtrap: identification and quantification of alternative polyadenylation sites from RNA-seq data
Motivation Alternative polyadenylation (APA) has been increasingly recognized as a crucial
mechanism that contributes to transcriptome diversity and gene expression regulation. As …
mechanism that contributes to transcriptome diversity and gene expression regulation. As …
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1
Myotonic dystrophy type I (DM1) is a multisystemic autosomal-dominant inherited human
disorder that is caused by CTG microsatellite repeat expansions (MREs) in the 3 …
disorder that is caused by CTG microsatellite repeat expansions (MREs) in the 3 …
Therapeutic potential of AntagomiR-23b for treating myotonic dystrophy
E Cerro-Herreros, I González-Martínez… - … Therapy-Nucleic Acids, 2020 - cell.com
Myotonic dystrophy type 1 (DM1) is a chronically debilitating, rare genetic disease that
originates from an expansion of a noncoding CTG repeat in the dystrophia myotonica …
originates from an expansion of a noncoding CTG repeat in the dystrophia myotonica …
[HTML][HTML] RNA-mediated therapies in myotonic dystrophy
Highlights•RNA medicine shows promise in DM1 therapeutics by targeting toxic CUG
expansions.•Restoring function of Muscleblind-like proteins is especially important in …
expansions.•Restoring function of Muscleblind-like proteins is especially important in …
Poly (A)-seq: A method for direct sequencing and analysis of the transcriptomic poly (A)-tails
F Yu, Y Zhang, C Cheng, W Wang, Z Zhou, W Rang… - PloS one, 2020 - journals.plos.org
Poly (A) tails at the 3'end of eukaryotic messenger RNAs control mRNA stability and
translation efficiency. Facilitated by various NGS methods, alternative polyadenylation sites …
translation efficiency. Facilitated by various NGS methods, alternative polyadenylation sites …
A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data
Alternative polyadenylation (APA) has been implicated to play an important role in post-
transcriptional regulation by regulating mRNA abundance, stability, localization and …
transcriptional regulation by regulating mRNA abundance, stability, localization and …
Regulation of alternative polyadenylation in the yeast Saccharomyces cerevisiae by histone H3K4 and H3K36 methyltransferases
K Kaczmarek Michaels, S Mohd Mostafa… - Nucleic acids …, 2020 - academic.oup.com
Adjusting DNA structure via epigenetic modifications, and altering polyadenylation (pA) sites
at which precursor mRNA is cleaved and polyadenylated, allows cells to quickly respond to …
at which precursor mRNA is cleaved and polyadenylated, allows cells to quickly respond to …