Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

Reactive oxygen species (ROS) is a term encompassing a group of highly reactive oxygen-
derived molecules. In physiological systems, ROS production exists in concert with …

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …

In eukaryotic cells, macromolecular homeostasis requires selective degradation of damaged
units by the ubiquitin-proteasome system (UPS) and autophagy. Thus, dysfunctional …

Abstract The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the
adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical …