Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Antibiotic resistance is one of the major challenges facing modern medicine worldwide. The
past few decades have witnessed rapid progress in our understanding of the multiple factors …

Collateral sensitivity (CS) is an evolutionary trade-off traditionally linked to the mutational
acquisition of antibiotic resistance (AR). However, AR can be temporally induced, and the …

Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished
the efficacy of almost all available antibiotics, complicating efforts to combat the spread of …

Bacterial populations vary in their stress tolerance and population structure depending upon
whether growth occurs in well-mixed or structured environments. We hypothesized that …

Background The clonal diversity underpinning trends in multidrug resistant Escherichia coli
causing bloodstream infections remains uncertain. We aimed to determine the contribution …

Collateral sensitivity is an evolutionary trade-off whereby acquisition of the adaptive
phenotype of resistance to an antibiotic leads to the nonadaptive increased susceptibility to …

Antibiotic resistance increasingly limits the success of antibiotic treatments, and physicians
require new ways to achieve efficient treatment despite resistance. Resistance mechanisms …

Evolved resistance to one antibiotic may be associated with" collateral" sensitivity to other
drugs. Here, we provide an extensive quantitative characterization of collateral effects in …