Source and impact of the EGF family of ligands on intestinal stem cells
Epidermal Growth Factor (EGF) has long been known for its role in promoting proliferation of
intestinal epithelial cells. EGF is produced by epithelial niche cells at the base of crypts in …
intestinal epithelial cells. EGF is produced by epithelial niche cells at the base of crypts in …
Regulation of energy metabolism by receptor tyrosine kinase ligands
Metabolic diseases, such as diabetes, obesity, and fatty liver disease, have now reached
epidemic proportions. Receptor tyrosine kinases (RTKs) are a family of cell surface …
epidemic proportions. Receptor tyrosine kinases (RTKs) are a family of cell surface …
Genetic and metabolic links between the murine microbiome and memory
Background Recent evidence has linked the gut microbiome to host behavior via the gut–
brain axis [1–3]; however, the underlying mechanisms remain unexplored. Here, we …
brain axis [1–3]; however, the underlying mechanisms remain unexplored. Here, we …
Genome-wide association of endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia (COGS) study
Importance The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …
Neuregulin 3 mediates cortical plate invasion and laminar allocation of GABAergic interneurons
Neural circuits in the cerebral cortex consist of excitatory pyramidal cells and inhibitory
interneurons. These two main classes of cortical neurons follow largely different genetic …
interneurons. These two main classes of cortical neurons follow largely different genetic …
[HTML][HTML] Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape (Brassica napus L.)
HK Woodfield, A Cazenave-Gassiot, RP Haslam… - … et Biophysica Acta (BBA …, 2018 - Elsevier
With dwindling available agricultural land, concurrent with increased demand for oil, there is
much current interest in raising oil crop productivity. We have been addressing this issue by …
much current interest in raising oil crop productivity. We have been addressing this issue by …
[PDF][PDF] ErbB4 signaling in dopaminergic axonal projections increases extracellular dopamine levels and regulates spatial/working memory behaviors
M Skirzewski, I Karavanova, A Shamir, L Erben… - Molecular …, 2018 - nature.com
Neuregulin (NRG) and its cognate neuronal receptor tyrosine kinase ErbB4 are genetically
associated with increased risk for schizophrenia and its endophenotyes. 1–4 Moreover …
associated with increased risk for schizophrenia and its endophenotyes. 1–4 Moreover …
NRG3 contributes to cognitive deficits in chronic patients with schizophrenia
Z Li, L Liu, W Lin, Y Zhou, G Zhang, X Du, Y Li… - Schizophrenia …, 2020 - Elsevier
Background Cognitive deficit is a fundamental trait of schizophrenia, but its mecwhanisms
remain unknown. The neuregulin 3 (NRG3) gene, involving in neuronal function, has been …
remain unknown. The neuregulin 3 (NRG3) gene, involving in neuronal function, has been …
Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3
Neuregulins (NRGs) are EGF-like ligands associated with cognitive disorders. Unprocessed
proNRG3 is cleaved by BACE1 to generate the mature membrane-bound NRG3 ligand, but …
proNRG3 is cleaved by BACE1 to generate the mature membrane-bound NRG3 ligand, but …
Interneuron odyssey: molecular mechanisms of tangential migration
I Toudji, A Toumi, É Chamberland… - Frontiers in Neural …, 2023 - frontiersin.org
Cortical GABAergic interneurons are critical components of neural networks. They provide
local and long-range inhibition and help coordinate network activities involved in various …
local and long-range inhibition and help coordinate network activities involved in various …