Emerging technologies for point-of-care CD4 T-lymphocyte counting

DS Boyle, KR Hawkins, MS Steele, M Singhal… - Trends in …, 2012 - cell.com
A CD4 T-lymphocyte count determines eligibility for antiretroviral therapy (ART) in patients
recently diagnosed with HIV and also monitors the efficacy of ART treatment thereafter. ART …

CD4 immunophenotyping in HIV infection

D Barnett, B Walker, A Landay, TN Denny - Nature Reviews …, 2008 - nature.com
The ability to rapidly identify immune cell subsets such as CD4 cells, which became possible
around the same time as the onset of the HIV/AIDS pandemic, was one of the greatest …

[HTML][HTML] Characterization of a new simian immunodeficiency virus strain in a naturally infected Pan troglodytes troglodyteschimpanzee with AIDS related symptoms

L Etienne, E Nerrienet, M LeBreton, GT Bibila… - Retrovirology, 2011 - Springer
Background Data on the evolution of natural SIV infection in chimpanzees (SIVcpz) and on
the impact of SIV on local ape populations are only available for Eastern African …

Role of the CD4 count in HIV management

J Hoffman, J Van Griensven, R Colebunders… - HIV therapy, 2010 - Taylor & Francis
As a result of successful antiretroviral treatment over the last 20 years, HIV has become
more of a chronic disease for practitioners to manage, requiring careful, but routine, clinical …

CD4 Count Pattern and Demographic Distribution of Treatment‐Naïve HIV Patients in Lagos, Nigeria

A Akinbami, A Dosunmu, A Adediran… - AIDS research and …, 2012 - Wiley Online Library
Background. CD4 count measures the degree of immunosuppression in HIV‐positive
patients. It is also used in deciding when to commence therapy, in staging the disease, and …

Biomarker detection of global infectious diseases based on magnetic particles

S Carinelli, M Marti, S Alegret, MI Pividori - New biotechnology, 2015 - Elsevier
Infectious diseases affect the daily lives of millions of people all around the world, and are
responsible for hundreds of thousands of deaths, mostly in the developing world. Although …

[HTML][HTML] CD4 enumeration technologies: a systematic review of test performance for determining eligibility for antiretroviral therapy

RW Peeling, KA Sollis, S Glover, SM Crowe… - PLoS …, 2015 - journals.plos.org
Background Measurement of CD4+ T-lymphocytes (CD4) is a crucial parameter in the
management of HIV patients, particularly in determining eligibility to initiate antiretroviral …

Electrochemical magneto-actuated biosensor for CD4 count in AIDS diagnosis and monitoring

S Carinelli, CX Ballesteros, M Martí, S Alegret… - Biosensors and …, 2015 - Elsevier
The counting of CD4+ T lymphocytes is a clinical parameter used for AIDS diagnosis and
follow-up. As this disease is particularly prevalent in developing countries, simple and …

Thirty‐five years of CD4 T‐cell counting in HIV infection: From flow cytometry in the lab to point‐of‐care testing in the field

L Kestens, F Mandy - Cytometry Part B: Clinical Cytometry, 2017 - Wiley Online Library
CD4 T‐cell counting was introduced in clinical laboratories shortly after the discovery of the
human immune deficiency virus (HIV) in the early eighties. In western clinical laboratories …

CD4 quantification based on magneto ELISA for AIDS diagnosis in low resource settings

S Carinelli, C Xufre, S Alegret, M Marti, MI Pividori - Talanta, 2016 - Elsevier
Abstract The Acquired Immune Deficiency Syndrome (AIDS) affects the life of millions of
people around the world. Although rapid and low cost screening tests are widely available …