The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

Usher syndrome (USH), clinically and genetically heterogeneous, is the leading genetic
cause of combined hearing and vision loss. USH is classified into three types, based on the …

Usher syndrome (USH) is the most common cause of deaf–blindness in humans, with a
prevalence of about 1/10,000 (~ 400,000 people worldwide). Cochlear implants are …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
signaling molecules and regulate a host of physiological and disease processes. To better …

Much is known about the mechanotransducer (MT) channels mediating transduction in hair
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …

There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

Adhesion-type heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptors (Adhesion-GPCRs) comprise a class of widely distributed seven-transmembrane …

Mammals have an astonishing ability to sense and discriminate sounds of different
frequencies and intensities. Fundamental for this process are mechanosensory hair cells in …

G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control
cellular states in response to soluble extracellular cues. However, the modality of stimuli …

Adhesion G protein-coupled receptors: structure, signaling, physiology, and
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …