International union of basic and clinical pharmacology. xciv. adhesion g protein–coupled receptors
The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …
[HTML][HTML] Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities
Usher syndrome (USH), clinically and genetically heterogeneous, is the leading genetic
cause of combined hearing and vision loss. USH is classified into three types, based on the …
cause of combined hearing and vision loss. USH is classified into three types, based on the …
The genetic and phenotypic landscapes of Usher syndrome: from disease mechanisms to a new classification
S Delmaghani, A El-Amraoui - Human Genetics, 2022 - Springer
Usher syndrome (USH) is the most common cause of deaf–blindness in humans, with a
prevalence of about 1/10,000 (~ 400,000 people worldwide). Cochlear implants are …
prevalence of about 1/10,000 (~ 400,000 people worldwide). Cochlear implants are …
[HTML][HTML] Anatomical profiling of G protein-coupled receptor expression
JB Regard, IT Sato, SR Coughlin - Cell, 2008 - cell.com
G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
signaling molecules and regulate a host of physiological and disease processes. To better …
signaling molecules and regulate a host of physiological and disease processes. To better …
The physiology of mechanoelectrical transduction channels in hearing
R Fettiplace, KX Kim - Physiological reviews, 2014 - journals.physiology.org
Much is known about the mechanotransducer (MT) channels mediating transduction in hair
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …
Mutations in G protein–coupled receptors: mechanisms, pathophysiology and potential therapeutic approaches
T Schöneberg, I Liebscher - Pharmacological reviews, 2021 - ASPET
There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …
these membrane receptors members of the most abundant gene family in the human …
Sticky signaling—adhesion class G protein–coupled receptors take the stage
T Langenhan, G Aust, J Hamann - Science signaling, 2013 - science.org
Adhesion-type heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptors (Adhesion-GPCRs) comprise a class of widely distributed seven-transmembrane …
receptors (Adhesion-GPCRs) comprise a class of widely distributed seven-transmembrane …
[HTML][HTML] Review series: The cell biology of hearing
Mammals have an astonishing ability to sense and discriminate sounds of different
frequencies and intensities. Fundamental for this process are mechanosensory hair cells in …
frequencies and intensities. Fundamental for this process are mechanosensory hair cells in …
The adhesion GPCR latrophilin/CIRL shapes mechanosensation
N Scholz, J Gehring, C Guan, D Ljaschenko, R Fischer… - Cell reports, 2015 - cell.com
G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control
cellular states in response to soluble extracellular cues. However, the modality of stimuli …
cellular states in response to soluble extracellular cues. However, the modality of stimuli …
Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology
T Lala, RA Hall - Physiological Reviews, 2022 - journals.physiology.org
Adhesion G protein-coupled receptors: structure, signaling, physiology, and
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …