Aging is a multifaceted and complicated process, manifested by a decline of normal
physiological functions across tissues and organs, leading to overt frailty, mortality, and …

Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and
differentiation. There is increasing evidence of the therapeutic value of MSCs in various …

Phenolic compounds are natural phytochemicals that have recently reported numerous
health benefits. Resveratrol, curcumin, and quercetin have recently received the most …

Mesenchymal stromal cell (MSC) metabolism plays a crucial role in the surrounding
microenvironment in both normal physiology and pathological conditions. While MSCs …

Osteoarthitis (OA) is the most common aging-related joint pathology; the aging process
results in changes to joint tissues that ultimately contribute to the development of OA …

Postmenopausal osteoporosis (OP) is one of the most common bone diseases that affects
millions of aging women. Reduced osteogenesis and increased oxidative stress have been …

Abstract Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase,
epigenetically regulates various cell metabolisms, including inflammation, tumorigenesis …

Reactive oxygen species (ROS) are implicated in induction of inflammatory response and
cartilage degradation in osteoarthritis (OA). Melatonin has been shown to improve the …

Mesenchymal stem cells (MSCs) are promising cell sources for regenerative medicine.
Growing evidence has indicated that mechanical stimuli are crucial for their lineage-specific …

Polyphenols, natural compounds rich in phenolic structures, are gaining prominence due to
their antioxidant, anti-inflammatory, antibacterial, and anticancer properties, making them …