The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

Obesity is a complex and heterogeneous condition that leads to various metabolic
complications, including type 2 diabetes. Unfortunately, for some, treatment options to date …

Introduction Obesity is a key target in the treatment and prevention of diabetes and
independently to reduce the burden of cardiovascular disease. We reviewed the options …

Obesity is a pandemic condition of complex etiology, resulting from the increasing exposition
to obesogenic environmental factors combined with genetic susceptibility. In the past two …

Context Unlike homozygous variants, the implication of heterozygous variants on the leptin–
melanocortin pathway in severe obesity has not been established. Objective To describe the …

Context Homozygous leptin (LEP) and leptin receptor (LEPR) variants lead to childhood-
onset obesity. Objective To present new cases with LEP and LEPR deficiency, report the …

Background Early childhood obesity is a public health problem worldwide. It affects different
aspects of physical and mental child's health. Identifying the etiologies, especially treatable …

The body of mammals harbors two distinct types of adipose tissue: while cells within the
white adipose tissue (WAT) store surplus energy as lipids, brown adipose tissue (BAT) is …

Leptin (LEP) and leptin receptor (LEPR) play a major role in energy homeostasis,
metabolism, and reproductive function. While effects of biallelic likely pathogenic variants …