Autophagy in healthy aging and disease

Y Aman, T Schmauck-Medina, M Hansen, RI Morimoto… - Nature aging, 2021 - nature.com
Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …

[HTML][HTML] Selective autophagy of intracellular organelles: recent research advances

W Li, P He, Y Huang, YF Li, J Lu, M Li, H Kurihara… - Theranostics, 2021 - ncbi.nlm.nih.gov
Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management

T Yadati, T Houben, A Bitorina, R Shiri-Sverdlov - Cells, 2020 - mdpi.com
Cathepsins are the most abundant lysosomal proteases that are mainly found in acidic
endo/lysosomal compartments where they play a vital role in intracellular protein …

The ménage à trois of autophagy, lipid droplets and liver disease

Y Filali-Mouncef, C Hunter, F Roccio, S Zagkou… - Autophagy, 2022 - Taylor & Francis
Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

AMPK as a therapeutic target for treating metabolic diseases

EA Day, RJ Ford, GR Steinberg - Trends in Endocrinology & Metabolism, 2017 - cell.com
The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …

Lipid droplets in cancer: guardians of fat in a stressful world

T Petan, E Jarc, M Jusović - Molecules, 2018 - mdpi.com
Cancer cells possess remarkable abilities to adapt to adverse environmental conditions.
Their survival during severe nutrient and oxidative stress depends on their capacity to …

Lysosomal biology and function: modern view of cellular debris bin

PC Trivedi, JJ Bartlett, T Pulinilkunnil - Cells, 2020 - mdpi.com
Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

Cyclodextrins, from molecules to applications

G Crini, S Fourmentin, É Fenyvesi, G Torri… - Environmental chemistry …, 2018 - Springer
Cyclodextrins are among the most remarkable macrocyclic molecules with significant
theoretical and practical impacts in chemistry and biology. Cyclodextrins belong to the family …

Autophagy in aging and longevity

SQ Wong, AV Kumar, J Mills, LR Lapierre - Human genetics, 2020 - Springer
Our understanding of the process of autophagy and its role in health and diseases has
grown remarkably in the last two decades. Early work established autophagy as a general …