The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

Collagen is a major component in a wide range of drug delivery systems and biomaterial
applications. Its basic physical and structural properties, together with its low …

The cells and tissues that make up our body manage contradictory mechanical demands. It
is crucial for their survival to be able to withstand large mechanical loads, but it is equally …

Overuse injuries to dense collagenous tissues are common, but their etiology is poorly
understood. The predominant hypothesis that micro-damage accumulation exceeds the rate …

The development of hydrogel-based biomaterials represents a promising approach to
generating new strategies for tissue engineering and regenerative medicine. In order to …

The collagen molecular family is the result of nearly one billion years of evolution. It is a
unique family of proteins, the majority of which provide general mechanical support to …

Interstitial collagen mechanical and biological properties are altered by proteases that
catalyze the hydrolysis of the collagen triple-helical structure. Collagenolysis is critical in …

Collagen, classically derived from animal tissue, is an all-important protein material widely
used in biomedical materials, cosmetics, fodder, food, etc. The production of recombinant …

Collagenous tissues, made of collagen molecules, such as tendon and bone, are intriguing
materials that have the ability to respond to mechanical forces by altering their structures …

Tissue homeostasis depends on a balance of synthesis and degradation of constituent
proteins, with turnover of a given protein potentially regulated by its use. Extracellular matrix …