The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer's disease

MG Fronza, D Alves, D Praticò, L Savegnago - Ageing research reviews, 2023 - Elsevier
Alzheimer's Disease (AD) is the most common form of dementia, affecting almost 50 million
of people around the world, characterized by a complex and age-related progressive …

Neuroprotective effects of cholinesterase inhibitors: current scenario in therapies for Alzheimer's disease and future perspectives

NCS Moreira, JEBF Lima, MF Marchiori… - Journal of …, 2022 - content.iospress.com
Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease
conceptualized as a continuous process, ranging from mild cognitive impairment (MCI), to …

Medicinal chemistry of indane and its analogues: A mini review

P Prasher, M Sharma - ChemistrySelect, 2021 - Wiley Online Library
Abstract 'Indane′ and its analogues indene, 1‐indenone, and 1, 3‐indandione present an
attractive biological profile for the rational development of therapeutic molecules. The …

Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Rosmarinus officinalis against Alzheimer's Disease

FJ Mirza, S Zahid, S Amber, H Jabeen, N Asim… - Molecules, 2022 - mdpi.com
Alzheimer's disease (AD) has been associated with the hallmark features of cholinergic
dysfunction, amyloid beta (Aβ) aggregation and impaired synaptic transmission, which …

Perspectives for new and more efficient multifunctional ligands for Alzheimer′ s disease therapy

A Zagórska, A Jaromin - Molecules, 2020 - mdpi.com
Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …

Diplazium esculentum (Retz.) Sw. reduces BACE-1 activities and amyloid peptides accumulation in Drosophila models of Alzheimer's disease

T Kunkeaw, U Suttisansanee, D Trachootham… - Scientific Reports, 2021 - nature.com
Abstract Alzheimer's disease (AD), one type of dementia, is a complex disease affecting
people globally with limited drug treatment. Thus, natural products are currently of interest as …

Recent advances in the development of polydiacetylene-based biosensors

Z Zhang, F Wang, X Chen - Chinese Chemical Letters, 2019 - Elsevier
Biosensors that effectively and selectively detect biomolecules and monitor biological
processes have become an important component of biological and medical studies …

BACE1 inhibitors: A promising therapeutic approach for the management of Alzheimer's disease

R Arya, S Jain, S Paliwal, K Madan… - Asian Pacific Journal …, 2024 - journals.lww.com
Alzheimer's disease is a neurological disorder marked by the accumulation of amyloid beta
(Aβ) aggregates, resulting from mutations in the amyloid precursor protein. The enzyme β …

Synthesis, bioassay and molecular docking of novel pyrazole and pyrazolone derivatives as acetylcholinesterase inhibitors

M Messaad, I Dhouib, M Abdelhedi… - Journal of Molecular …, 2022 - Elsevier
Pyrazole and pyrazolone derivatives have attracted growing interest over the years because
of their versatile applications in various fields. In this work, we describe the condensation of …

Enhancing Therapeutic Efficacy of Donepezil, an Alzheimer's Disease Drug, by Diplazium esculentum (Retz.) Sw. and Its Phytochemicals

W Inthachat, B Chantong, P Pitchakarn, C Takoon… - Pharmaceuticals, 2024 - mdpi.com
Alzheimer's disease (AD) is the most common type of dementia and a significant concern to
global public health due to the prevalence of aging populations. Donepezil is one of only a …