The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer's disease
Alzheimer's Disease (AD) is the most common form of dementia, affecting almost 50 million
of people around the world, characterized by a complex and age-related progressive …
of people around the world, characterized by a complex and age-related progressive …
Neuroprotective effects of cholinesterase inhibitors: current scenario in therapies for Alzheimer's disease and future perspectives
Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease
conceptualized as a continuous process, ranging from mild cognitive impairment (MCI), to …
conceptualized as a continuous process, ranging from mild cognitive impairment (MCI), to …
Medicinal chemistry of indane and its analogues: A mini review
P Prasher, M Sharma - ChemistrySelect, 2021 - Wiley Online Library
Abstract 'Indane′ and its analogues indene, 1‐indenone, and 1, 3‐indandione present an
attractive biological profile for the rational development of therapeutic molecules. The …
attractive biological profile for the rational development of therapeutic molecules. The …
Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Rosmarinus officinalis against Alzheimer's Disease
Alzheimer's disease (AD) has been associated with the hallmark features of cholinergic
dysfunction, amyloid beta (Aβ) aggregation and impaired synaptic transmission, which …
dysfunction, amyloid beta (Aβ) aggregation and impaired synaptic transmission, which …
Perspectives for new and more efficient multifunctional ligands for Alzheimer′ s disease therapy
A Zagórska, A Jaromin - Molecules, 2020 - mdpi.com
Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …
Diplazium esculentum (Retz.) Sw. reduces BACE-1 activities and amyloid peptides accumulation in Drosophila models of Alzheimer's disease
T Kunkeaw, U Suttisansanee, D Trachootham… - Scientific Reports, 2021 - nature.com
Abstract Alzheimer's disease (AD), one type of dementia, is a complex disease affecting
people globally with limited drug treatment. Thus, natural products are currently of interest as …
people globally with limited drug treatment. Thus, natural products are currently of interest as …
Recent advances in the development of polydiacetylene-based biosensors
Z Zhang, F Wang, X Chen - Chinese Chemical Letters, 2019 - Elsevier
Biosensors that effectively and selectively detect biomolecules and monitor biological
processes have become an important component of biological and medical studies …
processes have become an important component of biological and medical studies …
BACE1 inhibitors: A promising therapeutic approach for the management of Alzheimer's disease
Alzheimer's disease is a neurological disorder marked by the accumulation of amyloid beta
(Aβ) aggregates, resulting from mutations in the amyloid precursor protein. The enzyme β …
(Aβ) aggregates, resulting from mutations in the amyloid precursor protein. The enzyme β …
Synthesis, bioassay and molecular docking of novel pyrazole and pyrazolone derivatives as acetylcholinesterase inhibitors
M Messaad, I Dhouib, M Abdelhedi… - Journal of Molecular …, 2022 - Elsevier
Pyrazole and pyrazolone derivatives have attracted growing interest over the years because
of their versatile applications in various fields. In this work, we describe the condensation of …
of their versatile applications in various fields. In this work, we describe the condensation of …
Enhancing Therapeutic Efficacy of Donepezil, an Alzheimer's Disease Drug, by Diplazium esculentum (Retz.) Sw. and Its Phytochemicals
W Inthachat, B Chantong, P Pitchakarn, C Takoon… - Pharmaceuticals, 2024 - mdpi.com
Alzheimer's disease (AD) is the most common type of dementia and a significant concern to
global public health due to the prevalence of aging populations. Donepezil is one of only a …
global public health due to the prevalence of aging populations. Donepezil is one of only a …